Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation.

by Vikas Navratna, Dilip K Tosh, Kenneth A Jacobson, Eric Gouaux
Published 2018-01-01

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.

by Silvia Paoletta, Dilip K Tosh, Daniela Salvemini, Kenneth A Jacobson
Published 2014-01-01

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

by Kenneth A. Jacobson, Dilip K. Tosh, Shanu Jain, Zhan-Guo Gao
Published 2019-03-01

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

by Kenneth A. Jacobson, Zhan-Guo Gao, Silvia Paoletta, Evgeny Kiselev, Saibal Chakraborty, P. Suresh Jayasekara, Ramachandran Balasubramanian, Dilip K. Tosh
Published 2015-01-01

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists

by Dilip K. Tosh, Antonella Ciancetta, Philip Mannes, Eugene Warnick, Aaron Janowsky, Amy J. Eshleman, Elizabeth Gizewski, Tarsis F. Brust, Laura M. Bohn, John A. Auchampach, Zhan-Guo Gao, Kenneth A. Jacobson
Published 2018-10-01