Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

by Diego Balboa, Jere Weltner, Solja Eurola, Ras Trokovic, Kirmo Wartiovaara, Timo Otonkoski
Published 2015-09-01

Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9

by Diego Balboa, Jere Weltner, Yuval Novik, Solja Eurola, Kirmo Wartiovaara, Timo Otonkoski
Published 2017-07-01

Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9

by Diego Balboa, Jere Weltner, Yuval Novik, Solja Eurola, Kirmo Wartiovaara, Timo Otonkoski
Published 2017-08-01

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1.

by Kaisa Tamminen, Diego Balboa, Sanna Toivonen, Mikko P Pakarinen, Zoltan Wiener, Kari Alitalo, Timo Otonkoski
Published 2015-01-01

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes

by Diego Balboa, Diepiriye G. Iworima, Diepiriye G. Iworima, Timothy J. Kieffer, Timothy J. Kieffer, Timothy J. Kieffer
Published 2021-03-01

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

by Elisa Närvä, Aki Stubb, Camilo Guzmán, Matias Blomqvist, Diego Balboa, Martina Lerche, Markku Saari, Timo Otonkoski, Johanna Ivaska
Published 2017-07-01

A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions

by Joni Nikkanen, Juan Cruz Landoni, Diego Balboa, Maarja Haugas, Juha Partanen, Anders Paetau, Pirjo Isohanni, Virginia Brilhante, Anu Suomalainen
Published 2018-01-01

Human pluripotent reprogramming with CRISPR activators

by Jere Weltner, Diego Balboa, Shintaro Katayama, Maxim Bespalov, Kaarel Krjutškov, Eeva-Mari Jouhilahti, Ras Trokovic, Juha Kere, Timo Otonkoski
Published 2018-07-01

Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

by Endrit Elbasani, Francesca Falasco, Silvia Gramolelli, Veijo Nurminen, Thomas Günther, Jere Weltner, Diego Balboa, Adam Grundhoff, Timo Otonkoski, Päivi M. Ojala
Published 2020-08-01

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells

by Carina Lund, Venkatram Yellapragada, Sanna Vuoristo, Diego Balboa, Sara Trova, Cecile Allet, Nazli Eskici, Kristiina Pulli, Paolo Giacobini, Timo Tuuri, Taneli Raivio
Published 2020-03-01

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

by Svetlana Konovalova, Xiaonan Liu, Pooja Manjunath, Sundar Baral, Nirajan Neupane, Taru Hilander, Yang Yang, Diego Balboa, Mügen Terzioglu, Liliya Euro, Markku Varjosalo, Henna Tyynismaa
Published 2018-10-01

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

by Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Published 2018-11-01

Selective microRNA-Offset RNA expression in human embryonic stem cells.

by Suvi Asikainen, Liisa Heikkinen, Juuso Juhila, Frida Holm, Jere Weltner, Ras Trokovic, Milla Mikkola, Sanna Toivonen, Diego Balboa, Riina Lampela, Katherine Icay, Timo Tuuri, Timo Otonkoski, Garry Wong, Outi Hovatta
Published 2015-01-01

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

by Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Published 2017-04-01

Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

by Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Published 2019-02-01

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

by Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Published 2019-02-01