SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae

by Michael D. Paxhia, Diana M. Downs
Published 2019-02-01

Metabolic network structure and function in bacteria goes beyond conserved enzyme components

by Jannell V. Bazurto, Diana M. Downs
Published 2016-04-01

Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro.

by Kelsey M Hodge-Hanson, Diana M Downs
Published 2017-01-01

Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae

by Dustin C. Ernst, Diana M. Downs, Susan Gottesman
Published 2018-02-01

Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways.

by Dustin C Ernst, Andrew J Borchert, Diana M Downs
Published 2018-01-01

An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis

by Jannell V. Bazurto, Kristen R. Farley, Diana M. Downs
Published 2016-01-01

Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica

by Andrew J. Borchert, Goncalo J. Gouveia, Arthur S. Edison, Diana M. Downs
Published 2020-03-01

Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica.

by Melissa R Christopherson, Jennifer A Lambrecht, Deanna Downs, Diana M Downs
Published 2012-01-01

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica.

by Mark J Koenigsknecht, Jennifer A Lambrecht, Luke A Fenlon, Diana M Downs
Published 2012-01-01

The three-legged stool of understanding metabolism: integrating metabolomics with biochemical genetics and computational modeling

by Diana M. Downs, Jannell V. Bazurto, Anuj Gupta, Luis L. Fonseca, Eberhard O. Voit
Published 2018-04-01

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

by Jannell V. Bazurto, Stephen P. Dearth, Eric D. Tague, Shawn R. Campagna, Diana M. Downs
Published 2017-11-01

Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in <i>Salmonella enterica</i>

by Andrew J. Borchert, Jacquelyn M. Walejko, Adrien Le Guennec, Dustin C. Ernst, Arthur S. Edison, Diana M. Downs
Published 2019-12-01

Cj1388 Is a RidA Homolog and Is Required for Flagella Biosynthesis and/or Function in Campylobacter jejuni

by Jessica Irons, Jessica C. Sacher, Christine M. Szymanski, Christine M. Szymanski, Christine M. Szymanski, Diana M. Downs
Published 2019-09-01