Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease

by Tamiko R. Katsumoto, Shelia M. Violette, Dean Sheppard
Published 2011-01-01

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.

by Maike Thamsen, Rajarshi Ghosh, Vincent C Auyeung, Alexis Brumwell, Harold A Chapman, Bradley J Backes, Gayani Perara, Dustin J Maly, Dean Sheppard, Feroz R Papa
Published 2019-01-01

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

by Tatsuya Tsukui, Kai-Hui Sun, Joseph B. Wetter, John R. Wilson-Kanamori, Lisa A. Hazelwood, Neil C. Henderson, Taylor S. Adams, Jonas C. Schupp, Sergio D. Poli, Ivan O. Rosas, Naftali Kaminski, Michael A. Matthay, Paul J. Wolters, Dean Sheppard
Published 2020-04-01

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

by Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Joaquim Grego-Bessa, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, Denny Schanze, Pau Castel, Kentaro Hirose, Guo N. Huang, Martin Zenker, Dean Sheppard, Ophir D. Klein, David A. Tuveson, Benjamin S. Braun, Kevin Shannon
Published 2020-11-01

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.

by Victoria A Meliopoulos, Lee-Ann Van de Velde, Nicholas C Van de Velde, Erik A Karlsson, Geoff Neale, Peter Vogel, Cliff Guy, Shalini Sharma, Susu Duan, Sherri L Surman, Bart G Jones, Michael D L Johnson, Catharine Bosio, Lisa Jolly, R Gisli Jenkins, Julia L Hurwitz, Jason W Rosch, Dean Sheppard, Paul G Thomas, Peter J Murray, Stacey Schultz-Cherry
Published 2016-08-01