Applications of Alternative Nucleases in the Age of CRISPR/Cas9

by Tuhin K. Guha, David R. Edgell
Published 2017-11-01

Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.

by Benjamin P Kleinstiver, Wesley Bérubé-Janzen, Andrew D Fernandes, David R Edgell
Published 2011-01-01

Trans-Kingdom Conjugation within Solid Media from <i>Escherichia coli</i> to <i>Saccharomyces cerevisiae</i>

by Maximillian P. M. Soltysiak, Rebecca S. Meaney, Samir Hamadache, Preetam Janakirama, David R. Edgell, Bogumil J. Karas
Published 2019-10-01

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

by Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes
Published 2018-09-01

Evolutionary and biogeographical implications of degraded LAGLIDADG endonuclease functionality and group I intron occurrence in stony corals (Scleractinia) and mushroom corals (Cor...

by Juan Sebastián Celis, David R Edgell, Björn Stelbrink, Daniel Wibberg, Torsten Hauffe, Jochen Blom, Jörn Kalinowski, Thomas Wilke
Published 2017-01-01

Cloning of <i>Thalassiosira pseudonana’s</i> Mitochondrial Genome in <i>Saccharomyces cerevisiae</i> and <i>Escherichia coli</i>

by Ryan R. Cochrane, Stephanie L. Brumwell, Arina Shrestha, Daniel J. Giguere, Samir Hamadache, Gregory B. Gloor, David R. Edgell, Bogumil J. Karas
Published 2020-10-01

Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing

by Thomas A. Hamilton, Gregory M. Pellegrino, Jasmine A. Therrien, Dalton T. Ham, Peter C. Bartlett, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Published 2019-10-01

Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

by Julienne C Kaiser, Alyssa N King, Jason C Grigg, Jessica R Sheldon, David R Edgell, Michael E P Murphy, Shaun R Brinsmade, David E Heinrichs
Published 2018-01-01

Designer Sinorhizobium meliloti strains and multi-functional vectors enable direct inter-kingdom DNA transfer.

by Stephanie L Brumwell, Michael R MacLeod, Tony Huang, Ryan R Cochrane, Rebecca S Meaney, Maryam Zamani, Ola Matysiakiewicz, Kaitlyn N Dan, Preetam Janakirama, David R Edgell, Trevor C Charles, Turlough M Finan, Bogumil J Karas
Published 2019-01-01