Overcoming mutation-based resistance to antiandrogens with rational drug design

by Minna D Balbas, Michael J Evans, David J Hosfield, John Wongvipat, Vivek K Arora, Philip A Watson, Yu Chen, Geoffrey L Greene, Yang Shen, Charles L Sawyers
Published 2013-04-01

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

by Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles Brown, Geoffrey L Greene
Published 2018-11-01