Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model

by Daniel Knappe, Daniel Knappe, Daniel Knappe, Rico Schmidt, Rico Schmidt, Knut Adermann, Ralf Hoffmann, Ralf Hoffmann
Published 2019-10-01

Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum.

by Roland Böttger, Ralf Hoffmann, Daniel Knappe
Published 2017-01-01

Proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or human Klebsiella pneumoniae strain

by Ann-Kathrin Krieger, Daniel Knappe, Sophie Öhlmann, Leonie Mayer, Ines B. Eder, Gábor Köller, Ralf Hoffmann, Karoline Rieckmann, Christoph Georg Baums
Published 2021-03-01