Tissue Engineering Heart Valves – a Review of More than Two Decades into Preclinical and Clinical Testing for Obtaining the Next Generation of Heart Valve Substitutes

by Dan SIMIONESCU, Marius Mihai HARPA, Agneta SIMIONESCU, Codrut OPRITA, Ionela MOVILEANU
Published 2021-09-01

Iron Oxide Nanoparticles Stimulates Extra-Cellular Matrix Production in Cellular Spheroids

by Megan Casco, Timothy Olsen, Austin Herbst, Grace Evans, Taylor Rothermel, Lauren Pruett, Dan Simionescu, Richard Visconti, Frank Alexis
Published 2017-01-01

Chemical stabilization of the extracellular matrix attenuates growth of experimentally induced abdominal aorta aneurysms in a large animal model

by Dan Simionescu, PhD, Megan Casco, PhD, Jake Turner, BS, Nicholas Rierson, BS, Jianing Yue, MD, PhD, Kelvin Ning, MS
Published 2020-01-01

Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease

by Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Geanina Voicu, Cristina Ana Constantinescu, Daniela Rebleanu, Madalina Fenyo, Dan Simionescu, Agneta Simionescu, Ileana Manduteanu, Adriana Georgescu
Published 2020-08-01

Pressurized Perfusion System for Obtaining Completely Acellular Pulmonary Valve Scaffolds for Tissue Engineering

by Ionela Movileanu, Klara Brinzaniuc, Marius Harpa, Dan Nistor, Ovidiu Cotoi, Preda Terezia, Al Hussein Hussam, Oana Moldovan, Adrian Man, Lucian Harceaga, Leslie Sierad, Dan Simionescu
Published 2019-11-01

Preclinical Testing of Living Tissue-Engineered Heart Valves for Pediatric Patients, Challenges and Opportunities

by Ionela Movileanu, Ionela Movileanu, Marius Harpa, Marius Harpa, Hussam Al Hussein, Hussam Al Hussein, Lucian Harceaga, Alexandru Chertes, Hamida Al Hussein, Georg Lutter, Thomas Puehler, Terezia Preda, Carmen Sircuta, Ovidiu Cotoi, Dan Nistor, Dan Nistor, Adrian Man, Bogdan Cordos, Radu Deac, Horatiu Suciu, Horatiu Suciu, Klara Brinzaniuc, Klara Brinzaniuc, Megan Casco, Leslie Sierad, Margarita Bruce, Dan Simionescu, Dan Simionescu, Agneta Simionescu
Published 2021-08-01

Developing the Tissue Engineered Heart Valve – a Descriptive Hemodynamic and Ultrasound in Vitro Characterization Study of Heart Valves in a Bioreactor

by Ionela MOVILEANU, Dan Octavian NISTOR, Leslie SIERAD, Klara BRINZANIUC, Codrut OPRITA, Marius Mihai HARPA, Terezia PREDA, Ovidiu COTOI, Hussam AL HUSSEIN, Hamida AL HUSSEIN, Alexandru CHERTES, Horatiu SUCIU, Agneta SIMIONESCU, Dan SIMIONESCU
Published 2021-09-01