Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

by Tiit Örd, Daima Örd, Minna U. Kaikkonen, Tõnis Örd
Published 2021-05-01

A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals.

by Tiit Örd, Tarmo Puurand, Daima Örd, Tarmo Annilo, Märt Möls, Maido Remm, Tõnis Örd
Published 2020-08-01

Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet.

by Tiit Örd, Jürgen Innos, Kersti Lilleväli, Triin Tekko, Silva Sütt, Daima Örd, Sulev Kõks, Eero Vasar, Tõnis Örd
Published 2014-01-01

Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.

by Valérie Carraro, Anne-Catherine Maurin, Sarah Lambert-Langlais, Julien Averous, Cédric Chaveroux, Laurent Parry, Céline Jousse, Daima Ord, Tõnis Ord, Pierre Fafournoux, Alain Bruhat
Published 2010-01-01