Differential Regulation of Echinocandin Targets Fks1 and Fks2 in <em>Candida glabrata </em>by the Post-Transcriptional Regulator Ssd1

by Kelley R. Healey, Padmaja Paderu, Xin Hou, Cristina Jimenez Ortigosa, Nicole Bagley, Biren Patel, Yanan Zhao, David S. Perlin
Published 2020-08-01

Preliminary Structural Elucidation of β-(1,3)-Glucan Synthase from <i>Candida glabrata</i> Using Cryo-Electron Tomography

by Cristina Jiménez-Ortigosa, Jennifer Jiang, Muyuan Chen, Xuyuan Kuang, Kelley R. Healey, Paul Castellano, Nikpreet Boparai, Steven J. Ludtke, David S. Perlin, Wei Dai
Published 2021-02-01

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant <i>Candida tropicalis</i>: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

by Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh
Published 2020-01-01

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

by Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin
Published 2019-06-01

Antifungal Drug Susceptibility and Genetic Characterization of Fungi Recovered from COVID-19 Patients

by Milena Kordalewska, Kevin D. Guerrero, Rocio Garcia-Rubio, Cristina Jiménez-Ortigosa, José R. Mediavilla, Marcus H. Cunningham, Frank Hollis, Tao Hong, Kar Fai Chow, Barry N. Kreiswirth, David S. Perlin
Published 2021-07-01

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

by Kelley R. Healey, Yanan Zhao, Winder B. Perez, Shawn R. Lockhart, Jack D. Sobel, Dimitrios Farmakiotis, Dimitrios P. Kontoyiannis, Dominique Sanglard, Saad J. Taj-Aldeen, Barbara D. Alexander, Cristina Jimenez-Ortigosa, Erika Shor, David S. Perlin
Published 2016-03-01