Apilimod

by Patrick J. Morris, Curtis Moore, Craig J. Thomas
Published 2017-05-01

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis

by Laura Vian, Mimi T. Le, Nathalia Gazaniga, Jacqueline Kieltyka, Christine Liu, Giuseppe Pietropaolo, Stefania Dell'Orso, Stephen R. Brooks, Yasuko Furumoto, Craig J. Thomas, Craig J. Thomas, John J. O'Shea, Giuseppe Sciumè, Massimo Gadina
Published 2019-12-01

KiRNet: Kinase-centered network propagation of pharmacological screen results

by Thomas Bello, Marina Chan, Martin Golkowski, Andrew G. Xue, Nithisha Khasnavis, Michele Ceribelli, Shao-En Ong, Craig J. Thomas, Taranjit S. Gujral
Published 2021-06-01

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

by Anton Simeonov, Ajit Jadhav, Ahmed A Sayed, Yuhong Wang, Michael E Nelson, Craig J Thomas, James Inglese, David L Williams, Christopher P Austin
Published 2008-01-01

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

by Anusara Daenthanasanmak, Yuquan Lin, Meili Zhang, Bonita R. Bryant, Michael N. Petrus, Richard N. Bamford, Craig J. Thomas, Milos D. Miljkovic, Kevin C. Conlon, Thomas A. Waldmann
Published 2021-01-01

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology.

by Teresa L Burgess, Joshua D Amason, Jeffrey S Rubin, Damien Y Duveau, Laurence Lamy, David D Roberts, Catherine L Farrell, James Inglese, Craig J Thomas, Thomas W Miller
Published 2020-01-01

Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer

by Anne M. Noonan, Amanda Cousins, David Anderson, Kristen P. Zeligs, Kristen Bunch, Lidia Hernandez, Yusuke Shibuya, Ian S. Goldlust, Rajarshi Guha, Marc Ferrer, Craig J. Thomas, Christina M. Annunziata
Published 2020-12-01

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.

by Antonella Antignani, Lesley Mathews Griner, Rajarshi Guha, Nathan Simon, Matteo Pasetto, Jonathan Keller, Manjie Huang, Evan Angelus, Ira Pastan, Marc Ferrer, David J FitzGerald, Craig J Thomas
Published 2016-01-01

The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors

by Joseph A. De Soto, Xianyan Wang, Yohei Tominaga, Rui-Hong Wang, Liu Cao, Wenhui Qiao, Cuiling Li, Xiaoling Xu, Amanda P. Skoumbourdis, Sheila A. Prindiville, Craig J. Thomas, Chu-Xia Deng
Published 2006-01-01

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

by Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts
Published 2019-10-01

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

by Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Published 2019-11-01

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

by Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden, Thales Papagiannakopoulos
Published 2017-10-01

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

by Jefferson J Doyle, Alexander J Doyle, Nicole K Wilson, Jennifer P Habashi, Djahida Bedja, Ryan E Whitworth, Mark E Lindsay, Florian Schoenhoff, Loretha Myers, Nick Huso, Suha Bachir, Oliver Squires, Benjamin Rusholme, Hamid Ehsan, David Huso, Craig J Thomas, Mark J Caulfield, Jennifer E Van Eyk, Daniel P Judge, Harry C Dietz, GenTAC Registry Consortium, MIBAVA Leducq Consortium
Published 2015-10-01

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.

by Jonathan A Lee, Paul Shinn, Susan Jaken, Sarah Oliver, Francis S Willard, Steven Heidler, Robert B Peery, Jennifer Oler, Shaoyou Chu, Noel Southall, Thomas S Dexheimer, Jeffrey Smallwood, Ruili Huang, Rajarshi Guha, Ajit Jadhav, Karen Cox, Christopher P Austin, Anton Simeonov, G Sitta Sittampalam, Saba Husain, Natalie Franklin, David J Wild, Jeremy J Yang, Jeffrey J Sutherland, Craig J Thomas
Published 2015-01-01

Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo

by Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, Emma Hughes, Patrick J. Morris, Jon C. Mirsalis, Linh H. Nguyen, Maria P. Arolfo, Bryan Koci, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Connie Schmaljohn, Lisa M. Johansen, Gene G. Olinger, Joshua T. Schiffer, Judith M. White
Published 2021-03-01