Rewiring of the Transcription Factor Network in Acute Myeloid Leukemia

by Salam A Assi, Constanze Bonifer, Peter N Cockerill
Published 2019-06-01

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming

by Sophie Kellaway, Paulynn S. Chin, Farnaz Barneh, Constanze Bonifer, Olaf Heidenreich
Published 2020-12-01

Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

by Monica Nafria, Constanze Bonifer, Edouard Guy Stanley, Elizabeth Siewsun Ng, Andrew George Elefanty
Published 2020-12-01

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

by Monica Nafria, Peter Keane, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Constanze Bonifer
Published 2020-05-01

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors

by Jane Gilmour, Leigh O’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen, Constanze Bonifer
Published 2019-06-01

The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus.

by Kristin A Sauter, M Amine Bouhlel, Julie O'Neal, David P Sester, Hiromi Tagoh, Richard M Ingram, Clare Pridans, Constanze Bonifer, David A Hume
Published 2013-01-01

Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

by Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J.L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Published 2021-04-01

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

by Anetta Ptasinska, Anna Pickin, Salam A. Assi, Paulynn Suyin Chin, Luke Ames, Roberto Avellino, Stephan Gröschel, Ruud Delwel, Peter N. Cockerill, Cameron S. Osborne, Constanze Bonifer
Published 2019-09-01

C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

by Chris van Oevelen, Samuel Collombet, Guillermo Vicent, Maarten Hoogenkamp, Cyrille Lepoivre, Aimee Badeaux, Lars Bussmann, Jose Luis Sardina, Denis Thieffry, Miguel Beato, Yang Shi, Constanze Bonifer, Thomas Graf
Published 2015-08-01

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML

by Justin Loke, Salam A. Assi, Maria Rosaria Imperato, Anetta Ptasinska, Pierre Cauchy, Yura Grabovska, Natalia Martinez Soria, Manoj Raghavan, H. Ruud Delwel, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Published 2017-05-01

Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc Min/+ mouse model of intestinal tumorigenesis

by Mark A. Hull, Richard J. Cuthbert, C. W. Stanley Ko, Daniel J. Scott, Elizabeth J. Cartwright, Gillian Hawcroft, Sarah L. Perry, Nicola Ingram, Ian M. Carr, Alexander F. Markham, Constanze Bonifer, P. Louise Coletta
Published 2017-07-01

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

by Vasily V. Grinev, Farnaz Barneh, Ilya M. Ilyushonak, Sirintra Nakjang, Job Smink, Anita van Oort, Richard Clough, Michael Seyani, Hesta McNeill, Mojgan Reza, Natalia Martinez-Soria, Salam A. Assi, Tatsiana V. Ramanouskaya, Constanze Bonifer, Olaf Heidenreich
Published 2021-01-01

Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets.

by M S Vijayabaskar, Debbie K Goode, Nadine Obier, Monika Lichtinger, Amber M L Emmett, Fatin N Zainul Abidin, Nisar Shar, Rebecca Hannah, Salam A Assi, Michael Lie-A-Ling, Berthold Gottgens, Georges Lacaud, Valerie Kouskoff, Constanze Bonifer, David R Westhead
Published 2019-11-01

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

by Anetta Ptasinska, Salam A. Assi, Natalia Martinez-Soria, Maria Rosaria Imperato, Jason Piper, Pierre Cauchy, Anna Pickin, Sally R. James, Maarten Hoogenkamp, Dan Williamson, Mengchu Wu, Daniel G. Tenen, Sascha Ott, David R. Westhead, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Published 2014-09-01

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature

by Pierre Cauchy, Sally R. James, Joaquin Zacarias-Cabeza, Anetta Ptasinska, Maria Rosaria Imperato, Salam A. Assi, Jason Piper, Martina Canestraro, Maarten Hoogenkamp, Manoj Raghavan, Justin Loke, Susanna Akiki, Samuel J. Clokie, Stephen J. Richards, David R. Westhead, Michael J. Griffiths, Sascha Ott, Constanze Bonifer, Peter N. Cockerill
Published 2015-08-01

Corrigendum to: “Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers” [EBioMedicine 8 (2016) 117–131]

by Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Published 2017-11-01

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

by Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Published 2016-06-01