The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

by Keith E. Campagno, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell
Published 2021-03-01

Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration

by Assraa Hassan Jassim, Denise M. Inman, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell
Published 2021-07-01

Neuronal release of cytokine IL-3 triggered by mechanosensitive autostimulation of the P2X7 receptor is neuroprotective

by Jason C Lim, Wennan Lu, Jonathan M Beckel, Claire H Mitchell, Claire H Mitchell, Claire H Mitchell
Published 2016-11-01

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

by Farraj Albalawi, Farraj Albalawi, Wennan Lu, Jonathan M. Beckel, Jonathan M. Beckel, Jason C. Lim, Stuart A. McCaughey, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell
Published 2017-08-01

The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration

by Wennan Lu, Néstor M. Gómez, Jason C. Lim, Sonia Guha, Sonia Guha, Ann O’Brien-Jenkins, Erin E. Coffey, Keith E. Campagno, Stuart A. McCaughey, Alan M. Laties, Leif G. Carlsson, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell
Published 2018-04-01

Polarized Cytokine Release Triggered by P2X7 Receptor from Retinal Pigmented Epithelial Cells Dependent on Calcium Influx

by Xiaolei Shao, Sonia Guha, Wennan Lu, Keith E. Campagno, Jonathan M. Beckel, Jason A. Mills, Wenli Yang, Claire H. Mitchell
Published 2020-11-01

Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

by Gabriel C Baltazar, Sonia Guha, Wennan Lu, Jason Lim, Kathleen Boesze-Battaglia, Alan M Laties, Puneet Tyagi, Uday B Kompella, Claire H Mitchell
Published 2012-01-01

<i>Aggregatibacter actinomycetemcomitans</i> LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes

by Edward T Lally, Kathleen Boesze-Battaglia, Anuradha Dhingra, Nestor M Gomez, Jinery Lora, Claire H Mitchell, Alexander Giannakakis, Syed A Fahim, Roland Benz, Nataliya Balashova
Published 2020-01-01

CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells

by Alan D. Workman, Ryan M. Carey, Bei Chen, Cecil J. Saunders, Philippe Marambaud, Claire H. Mitchell, Michael G. Tordoff, Robert J. Lee, Noam A. Cohen
Published 2017-07-01

Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

by Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Huen-Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez, Claire H. Mitchell
Published 2021-09-01

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

by Ju-Hyun Lee, Mary Kate McBrayer, Devin M. Wolfe, Luke J. Haslett, Asok Kumar, Yutaka Sato, Pearl P.Y. Lie, Panaiyur Mohan, Erin E. Coffey, Uday Kompella, Claire H. Mitchell, Emyr Lloyd-Evans, Ralph A. Nixon
Published 2015-09-01