MAPS: machine-assisted phenotype scoring enables rapid functional assessment of genetic variants by high-content microscopy

by Jesse T. Chao, Calvin D. Roskelley, Christopher J. R. Loewen
Published 2021-04-01

A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.

by Sujoy Lahiri, Jesse T Chao, Shabnam Tavassoli, Andrew K O Wong, Vineet Choudhary, Barry P Young, Christopher J R Loewen, William A Prinz
Published 2014-10-01

Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

by John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen
Published 2016-09-01

Viral proteins as a potential driver of histone depletion in dinoflagellates

by Nicholas A. T. Irwin, Benjamin J. E. Martin, Barry P. Young, Martin J. G. Browne, Andrew Flaus, Christopher J. R. Loewen, Patrick J. Keeling, LeAnn J. Howe
Published 2018-04-01

Mechanisms of PTPσ-Mediated Presynaptic Differentiation

by Claire Bomkamp, Nirmala Padmanabhan, Nirmala Padmanabhan, Nirmala Padmanabhan, Benyamin Karimi, Benyamin Karimi, Benyamin Karimi, Yuan Ge, Jesse T. Chao, Christopher J. R. Loewen, Tabrez J. Siddiqui, Tabrez J. Siddiqui, Tabrez J. Siddiqui, Ann Marie Craig
Published 2019-05-01

Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction

by Kathryn L. Post, Manuel Belmadani, Payel Ganguly, Fabian Meili, Riki Dingwall, Troy A. McDiarmid, Warren M. Meyers, Caitlin Herrington, Barry P. Young, Daniel B. Callaghan, Sanja Rogic, Matthew Edwards, Ana Niciforovic, Alessandro Cau, Catharine H. Rankin, Timothy P. O’Connor, Shernaz X. Bamji, Christopher J. R. Loewen, Douglas W. Allan, Paul Pavlidis, Kurt Haas
Published 2020-04-01