Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

by Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race, Cathryn L. Haigh
Published 2019-06-01

Factors That Improve RT-QuIC Detection of Prion Seeding Activity

by Christina D. Orrú, Andrew G. Hughson, Bradley R. Groveman, Katrina J. Campbell, Kelsie J. Anson, Matteo Manca, Allison Kraus, Byron Caughey
Published 2016-05-01

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

by Christina D Orrú, Bradley R Groveman, Lynne D Raymond, Andrew G Hughson, Romolo Nonno, Wenquan Zou, Bernardino Ghetti, Pierluigi Gambetti, Byron Caughey
Published 2015-06-01

Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

by Christina D Orrú, Bradley R Groveman, Lynne D Raymond, Andrew G Hughson, Romolo Nonno, Wenquan Zou, Bernardino Ghetti, Pierluigi Gambetti, Byron Caughey
Published 2015-08-01

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC.

by Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughey
Published 2012-01-01

Correction to: Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

by Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko, Byron Caughey
Published 2020-11-01

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

by Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko, Byron Caughey
Published 2018-02-01

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

by Jason M Wilham, Christina D Orrú, Richard A Bessen, Ryuichiro Atarashi, Kazunori Sano, Brent Race, Kimberly D Meade-White, Lara M Taubner, Andrew Timmes, Byron Caughey
Published 2010-12-01

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

by Bradley R Groveman, Gregory J Raymond, Katrina J Campbell, Brent Race, Lynne D Raymond, Andrew G Hughson, Christina D Orrú, Allison Kraus, Katie Phillips, Byron Caughey
Published 2017-09-01

A rapid α‐synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy

by Christina D. Orrù, Thong C. Ma, Andrew G. Hughson, Bradley R. Groveman, Ankit Srivastava, Douglas Galasko, Rachel Angers, Patrick Downey, Karen Crawford, Samantha J. Hutten, Un Jung Kang, Byron Caughey
Published 2021-02-01

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

by Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey
Published 2020-06-01

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients

by Christina D. Orrù, Katrin Soldau, Christian Cordano, Jorge Llibre-Guerra, Ari J. Green, Henry Sanchez, Bradley R. Groveman, Steven D. Edland, Jiri G. Safar, Jonathan H. Lin, Byron Caughey, Michael D. Geschwind, Christina J. Sigurdson
Published 2018-11-01

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.

by Fei Wang, Xinhe Wang, Christina D Orrú, Bradley R Groveman, Krystyna Surewicz, Romany Abskharon, Morikazu Imamura, Takashi Yokoyama, Yong-Sun Kim, Kayla J Vander Stel, Kumar Sinniah, Suzette A Priola, Witold K Surewicz, Byron Caughey, Jiyan Ma
Published 2017-07-01

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear

by Natalia C. Ferreira, Jorge M. Charco, Jakob Plagenz, Christina D. Orru, Nathanial D. Denkers, Michael A. Metrick, Andrew G. Hughson, Karen A. Griffin, Brent Race, Edward A. Hoover, Joaquín Castilla, Tracy A. Nichols, Michael W. Miller, Byron Caughey
Published 2021-04-01

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

by Christina D. Orrú, Bradley R. Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie, Audrey Culeux, Anna Poleggi, Katarina Grznarova, Daniela Perra, Michele Fiorini, Xiaoqin Liu, Anna Ladogana, Marco Sbriccoli, Andrew G. Hughson, Stéphane Haïk, Alison J. Green, Michael D. Geschwind, Maurizio Pocchiari, Jiri G. Safar, Gianluigi Zanusso, Byron Caughey
Published 2020-11-01

Early preclinical detection of prions in the skin of prion-infected animals

by Zerui Wang, Matteo Manca, Aaron Foutz, Manuel V. Camacho, Gregory J. Raymond, Brent Race, Christina D. Orru, Jue Yuan, Pingping Shen, Baiya Li, Yue Lang, Johnny Dang, Alise Adornato, Katie Williams, Nicholas R. Maurer, Pierluigi Gambetti, Bin Xu, Witold Surewicz, Robert B. Petersen, Xiaoping Dong, Brian S. Appleby, Byron Caughey, Li Cui, Qingzhong Kong, Wen-Quan Zou
Published 2019-01-01

Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals

by Zerui Wang, Matteo Manca, Aaron Foutz, Manuel V. Camacho, Gregory J. Raymond, Brent Race, Christina D. Orru, Jue Yuan, Pingping Shen, Baiya Li, Yue Lang, Johnny Dang, Alise Adornato, Katie Williams, Nicholas R. Maurer, Pierluigi Gambetti, Bin Xu, Witold Surewicz, Robert B. Petersen, Xiaoping Dong, Brian S. Appleby, Byron Caughey, Li Cui, Qingzhong Kong, Wen-Quan Zou
Published 2019-02-01