From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin

by Yu-Jen Chen, Chian-Shiu Chien, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng
Published 2021-06-01

Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation

by Hui-Yung Song, Yi-Ping Yang, Yueh Chien, Wei-Yi Lai, Yi-Ying Lin, Shih-Jie Chou, Mong-Lien Wang, Chien-Ying Wang, Hsin-Bang Leu, Wen-Chung Yu, Chian-Shiu Chien
Published 2021-02-01

Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1

by Aliaksandr A. Yarmishyn, Yi-Ping Yang, Kai-Hsi Lu, Yi-Chen Chen, Yueh Chien, Shih-Jie Chou, Ping-Hsing Tsai, Hsin-I. Ma, Chian-Shiu Chien, Ming-Teh Chen, Mong-Lien Wang
Published 2020-12-01

Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection

by Yanwen Liang, Yanwen Liang, Mong-Lien Wang, Mong-Lien Wang, Mong-Lien Wang, Chian-Shiu Chien, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Yi-Ping Yang, Yi-Ping Yang, Yi-Ping Yang, Wei-Yi Lai, Yung-Hung Luo, Yung-Hung Luo, Yi-Tsung Lin, Yann-Jang Chen, Yann-Jang Chen, Yann-Jang Chen, Pei-Ching Chang, Shih-Hwa Chiou, Shih-Hwa Chiou, Shih-Hwa Chiou, Shih-Hwa Chiou, Shih-Hwa Chiou
Published 2020-05-01

Generation of <i>GLA</i>-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy

by Hui-Yung Song, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Shih-Jie Chou, Yi-Ping Yang, Mong-Lien Wang, Chien-Ying Wang, Hsin-Bang Leu, Wen-Chung Yu, Yuh-Lih Chang, Shih-Hwa Chiou
Published 2019-04-01

Using CRISPR/Cas9-Mediated GLA Gene Knockout as an In Vitro Drug Screening Model for Fabry Disease

by Hui-Yung Song, Huai-Chih Chiang, Wei-Lien Tseng, Ping Wu, Chian-Shiu Chien, Hsin-Bang Leu, Yi-Ping Yang, Mong-Lien Wang, Yuh-Jyh Jong, Chung-Hsuan Chen, Wen-Chung Yu, Shih-Hwa Chiou
Published 2016-12-01

A Review of SARS-CoV-2 and the Ongoing Clinical Trials

by Yung-Fang Tu, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Yi-Ying Lin, Yung-Hung Luo, Yi-Tsung Lin, Wei-Yi Lai, De-Ming Yang, Shih-Jie Chou, Yi-Ping Yang, Mong-Lien Wang, Shih-Hwa Chiou
Published 2020-04-01

Current Genetic Survey and Potential Gene-Targeting Therapeutics for Neuromuscular Diseases

by Wei Chiu, Ya-Hsin Hsun, Kao-Jung Chang, Aliaksandr A. Yarmishyn, Yu-Jer Hsiao, Yueh Chien, Chian Shiu Chien, Chun Ma, Yi-Ping Yang, Ping-Hsing Tsai, Shih-Hwa Chiou, Ting-Yi Lin, Hao-Min Cheng
Published 2020-12-01

Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression

by Yi-Ping Yang, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Man-Sheung Chan, Andy Chi-Lung Lee, Yi-Wei Chen, Pin-I Huang, Hsin-I Ma, Wen-Liang Lo, Yueh Chien, Wen-Chang Lin, Mong-Lien Wang, Ming-Teh Chen
Published 2021-04-01

Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids

by Henkie Isahwan Ahmad Mulyadi Lai, Shih-Jie Chou, Yueh Chien, Ping-Hsing Tsai, Chian-Shiu Chien, Chih-Chien Hsu, Ying-Chun Jheng, Mong-Lien Wang, Shih-Hwa Chiou, Yu-Bai Chou, De-Kuang Hwang, Tai-Chi Lin, Shih-Jen Chen, Yi-Ping Yang
Published 2021-01-01

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

by Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Tai-Chi Lin, Aliaksandr A. Yarmishyn, Wun-Syuan Chen, De-Kuang Hwang, Guang-Yuh Chiou, Tzu-Wei Lin, Chian-Shiu Chien, Ching-Yao Tsai, Shih-Hwa Chiou, Shih-Jen Chen, Chi-Hsien Peng, Chih-Chien Hsu
Published 2019-06-01

Imbalanced Production of Reactive Oxygen Species and Mitochondrial Antioxidant SOD2 in Fabry Disease-Specific Human Induced Pluripotent Stem Cell-Differentiated Vascular Endothelia...

by Wei-Lien Tseng, Shih-Jie Chou, Huai-Chih Chiang, Mong-Lien Wang, Chian-Shiu Chien, Kuan-Hsuan Chen, Hsin-Bang Leu, Chien-Ying Wang, Yuh-Lih Chang, Yung-Yang Liu, Yuh-Jyh Jong, Shinn-Zong Lin, Shih-Hwa Chiou, Shing-Jong Lin, Wen-Chung Yu
Published 2017-03-01

Tumor Necrosis Factor-Alpha Exacerbates Viral Entry in SARS-CoV2-Infected iPSC-Derived Cardiomyocytes

by Chiu-Yang Lee, Chih-Heng Huang, Elham Rastegari, Vimalan Rengganaten, Ping-Cheng Liu, Ping-Hsing Tsai, Yuan-Fan Chin, Jing-Rong Wu, Shih-Hwa Chiou, Yuan-Chi Teng, Chih-Wei Lee, Yanwen Liang, An-Yu Chen, Shu-Chen Hsu, Yi-Jen Hung, Jun-Ren Sun, Chian-Shiu Chien, Yueh Chien
Published 2021-09-01

Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers

by Yung-Hung Luo, Yi-Ping Yang, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Afeez Adekunle Ishola, Yueh Chien, Yuh-Min Chen, Tsai-Wang Huang, Kang-Yun Lee, Wen-Chien Huang, Ping-Hsing Tsai, Tzu-Wei Lin, Shih-Hwa Chiou, Chao-Yu Liu, Cheng-Chang Chang, Ming-Teh Chen, Mong-Lien Wang
Published 2020-06-01

Dual DNA Transfection Using 1,6-Hexanedithiol-Conjugated Maleimide-Functionalized PU-PEI600 For Gene Correction in a Patient iPSC-Derived Fabry Cardiomyopathy Model

by Chian-Shiu Chien, Chian-Shiu Chien, Yueh Chien, Yueh Chien, Yi-Ying Lin, Yi-Ying Lin, Yi-Ying Lin, Ping-Hsing Tsai, Ping-Hsing Tsai, Ping-Hsing Tsai, Shih-Jie Chou, Shih-Jie Chou, Shih-Jie Chou, Aliaksandr A. Yarmishyn, Aliaksandr A. Yarmishyn, Elham Rastegari, Ting-Xian Wang, Hsin-Bang Leu, Hsin-Bang Leu, Yi-Ping Yang, Yi-Ping Yang, Yi-Ping Yang, Mong-Lien Wang, Mong-Lien Wang, Mong-Lien Wang, Ying-Chun Jheng, Henkie Isahwan Ahmad Mulyadi Lai, Henkie Isahwan Ahmad Mulyadi Lai, Lo-Jei Ching, Teh-Ia Huo, Teh-Ia Huo, Teh-Ia Huo, Teh-Ia Huo, Jong-Yuh Cherng, Chien-Ying Wang, Chien-Ying Wang
Published 2021-08-01

Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis...

by Shih‐Jie Chou, Peng Yang, Qian Ban, Yi‐Ping Yang, Mong‐Lien Wang, Chian‐Shiu Chien, Shih‐Jen Chen, Na Sun, Yazhen Zhu, Hongtao Liu, Wenqiao Hui, Tai‐Chi Lin, Fang Wang, Ryan Yue Zhang, Viet Q. Nguyen, Wenfei Liu, Mengxiang Chen, Steve J. Jonas, Paul S. Weiss, Hsian‐Rong Tseng, Shih‐Hwa Chiou
Published 2020-05-01

Enhanced Antioxidant Capacity of Dental Pulp-Derived iPSC-Differentiated Hepatocytes and Liver Regeneration by Injectable HGF-Releasing Hydrogel in Fulminant Hepatic Failure

by Chih-Hung Chiang, Wai-Wah Wu, Hsin-Yang Li, Yueh Chien, Cho-Chin Sun, Chi-Hsien Peng, Alex Tong-Long Lin, Chi-Shuan Huang, Ying-Hsiu Lai, Shih-Hwa Chiou, Shuen-Iu Hung, Yuh-Lih Chang, Yuan-Tzu Lan, Dean-Mo Liu, Chian-Shiu Chien, Teh-Ia Huo, Shou-Dong Lee, Chien-Ying Wang
Published 2015-03-01