Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions

by Chen, Fangyi, Bian, Ke, Tang, Qi, Humulock, Zachary T., Li, Deyu, Fedeles, Bogdan I, Singh, Vipender, Essigmann, John M.
Published 2018

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA

by Chen, Fangyi, Tang, Qi, Bian, Ke, Humulock, Zachary T., Yang, Xuedong, Li, Deyu, Jost, Marco, Drennan, Catherine L., Essigmann, John M.
Published 2018

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

by Bian, Ke, Lenz, Stefan A P, Tang, Qi, Chen, Fangyi, Qi, Rui, Jost, Marco, Drennan, Catherine L, Essigmann, John M, Wetmore, Stacey D, Li, Deyu
Published 2020