Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

by Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Published 2020-12-01

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

by Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Published 2018-10-01

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

by Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Published 2017-01-01