Emerging treatments for chronic hepatitis C

by C. Nelson Hayes, Kazuaki Chayama
Published 2015-03-01

HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy

by Kazuaki Chayama, C. Nelson Hayes
Published 2015-10-01

MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma

by C. Nelson Hayes, Kazuaki Chayama
Published 2016-02-01

Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection

by C. Nelson Hayes, Peiyi Zhang, Yizhou Zhang, Kazuaki Chayama
Published 2018-09-01

Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing

by Atsushi Ono, C. Nelson Hayes, Sakura Akamatsu, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Published 2017-01-01

Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological f...

by Naoyuki Ueda, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, C. Nelson Hayes, Michiya Yokozaki, Kazuaki Chayama
Published 2020-09-01

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay.

by Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Published 2015-01-01

Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis

by Hatsue Fujino, Mio Tanaka, Michio Imamura, Kei Morio, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Shoichi Takahashi, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C. Nelson Hayes, Kazuaki Chayama
Published 2019-10-01

Genomic Characterization of Non-Invasive Differentiated-Type Gastric Cancer in the Japanese Population

by Koki Nakamura, Yuji Urabe, Kenichi Kagemoto, Ryo Yuge, Ryohei Hayashi, Atsushi Ono, C. Nelson Hayes, Shiro Oka, Masanori Ito, Takashi Nishisaka, Kazuaki Tanabe, Koji Arihiro, Hideki Ohdan, Shinji Tanaka, Kazuaki Chayama
Published 2020-02-01

Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse.

by Masataka Tsuge, Yoshifumi Fujimoto, Nobuhiko Hiraga, Yizhou Zhang, Mayu Ohnishi, Tomohiko Kohno, Hiromi Abe, Daiki Miki, Michio Imamura, Shoichi Takahashi, Hidenori Ochi, C Nelson Hayes, Fuyuki Miya, Tatsuhiko Tsunoda, Kazuaki Chayama
Published 2011-01-01

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.

by C Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Rie Akiyama, Hiromi Abe, Hidenori Ochi, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Hiroshi Aikata, Tomokazu Kawaoka, Yoshiiku Kawakami, Waka Ohishi, Kazuaki Chayama
Published 2012-01-01

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus.

by Eisuke Miyaki, Nobuhiko Hiraga, Michio Imamura, Takuro Uchida, Hiromi Kan, Masataka Tsuge, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Masahiro Serikawa, Hiroshi Aikata, Hidenori Ochi, Yuji Ishida, Chise Tateno, Hideki Ohdan, Kazuaki Chayama
Published 2017-01-01

Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib

by Yasutoshi Fujii, Atsushi Ono, C. Nelson Hayes, Hiroshi Aikata, Masami Yamauchi, Shinsuke Uchikawa, Kenichiro Kodama, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge, Michio Imamura, Kazuaki Chayama
Published 2021-06-01

A case of acute liver failure with echovirus infection diagnosed by a multi-virus real-time PCR system

by Yuki Yoshikawa, Michio Imamura, Kei Morio, Kenji Yamaoka, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, C. Nelson Hayes, Hiroshi Aikata, Takaji Wakita, Harutaka Katano, Kazuaki Chayama
Published 2021-01-01

Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receivi...

by Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Waka Ohishi, Takeshi Kishi, Kazuki Ohya, Yuji Teraoka, Mitsutaka Osawa, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Tomokazu Kawaoka, Hiromi Abe-Chayama, Peiyi Zhang, Songyao Liu, Grace Naswa Makokha, Masataka Tsuge, Michio Imamura, C. Nelson Hayes, Kazuaki Chayama
Published 2020-05-01

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid BiopsySummary

by Atsushi Ono, Akihiro Fujimoto, Yujiro Yamamoto, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Tomokazu Kawaoka, Masataka Tsuge, Hiromi Abe, C. Nelson Hayes, Daiki Miki, Mayuko Furuta, Tatsuhiko Tsunoda, Satoru Miyano, Michiaki Kubo, Hiroshi Aikata, Hidenori Ochi, Yoshi-iku Kawakami, Koji Arihiro, Hideki Ohdan, Hidewaki Nakagawa, Kazuaki Chayama
Published 2015-09-01

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study.

by Daiki Miki, Hidenori Ochi, Atsushi Takahashi, C Nelson Hayes, Yuji Urabe, Hiromi Abe, Tomokazu Kawaoka, Masataka Tsuge, Nobuhiko Hiraga, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Shoichi Takahashi, Norio Akuta, Fumitaka Suzuki, Kenji Ikeda, Hiromitsu Kumada, Yoshiyasu Karino, Joji Toyota, Tatsuhiko Tsunoda, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura, Kazuaki Chayama
Published 2013-01-01

The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy.

by Yuko Nagaoki, Michio Imamura, Hiroshi Aikata, Kana Daijo, Yuji Teraoka, Fumi Honda, Yuki Nakamura, Masahiro Hatooka, Reona Morio, Kei Morio, Hiromi Kan, Hatsue Fujino, Tomoki Kobayashi, Keiichi Masaki, Atsushi Ono, Takashi Nakahara, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Yoshiiku Kawakami, C Nelson Hayes, Daiki Miki, Hidenori Ochi, Kazuaki Chayama
Published 2017-01-01

A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation.

by Yukiko Nakano, Kazuaki Chayama, Hidenori Ochi, Masaaki Toshishige, Yasufumi Hayashida, Daiki Miki, C Nelson Hayes, Hidekazu Suzuki, Takehito Tokuyama, Noboru Oda, Kazuyoshi Suenari, Yuko Uchimura-Makita, Kenta Kajihara, Akinori Sairaku, Chikaaki Motoda, Mai Fujiwara, Yoshikazu Watanabe, Yukihiko Yoshida, Kimie Ohkubo, Ichiro Watanabe, Akihiko Nogami, Kanae Hasegawa, Hiroshi Watanabe, Naoto Endo, Takeshi Aiba, Wataru Shimizu, Seiko Ohno, Minoru Horie, Koji Arihiro, Satoshi Tashiro, Naomasa Makita, Yasuki Kihara
Published 2013-04-01