Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium

by Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe
Published 2020-01-01

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts.

by Tae Yun Kim, Celinda M Kofron, Michelle E King, Alexander R Markes, Amenawon O Okundaye, Zhilin Qu, Ulrike Mende, Bum-Rak Choi
Published 2018-01-01

Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxyg...

by Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Published 2018-12-01

A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues

by Celinda M. Kofron, Tae Yun Kim, Fabiola Munarin, Arvin H. Soepriatna, Rajeev J. Kant, Ulrike Mende, Bum-Rak Choi, Kareen L. K. Coulombe
Published 2021-05-01

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.

by Emily Lau, Konstantinos Kossidas, Tae Yun Kim, Yukiko Kunitomo, Ohad Ziv, Zhen Song, Chantel Taylor, Lorraine Schofield, Joe Yammine, Gongxin Liu, Xuwen Peng, Zhilin Qu, Gideon Koren, Bum-Rak Choi
Published 2015-01-01

Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.

by Emily Lau, Konstantinos Kossidas, Tae Yun Kim, Yukiko Kunitomo, Ohad Ziv, Zhen Song, Chantel Taylor, Lorraine Schofield, Joe Yammine, Gongxin Liu, Xuwen Peng, Zhilin Qu, Gideon Koren, Bum-Rak Choi
Published 2015-01-01

Associations of Prolonged QTc in Sickle Cell Disease.

by Julia H Indik, Vineet Nair, Ruslan Rafikov, Iwan S Nyotowidjojo, Jaskanwal Bisla, Mayank Kansal, Devang S Parikh, Melissa Robinson, Anand Desai, Megha Oberoi, Akash Gupta, Taimur Abbasi, Zain Khalpey, Amit R Patel, Roberto M Lang, Samuel C Dudley, Bum-Rak Choi, Joe G N Garcia, Roberto F Machado, Ankit A Desai
Published 2016-01-01