Convergence of external Crohn’s disease risk factors on intestinal bacteria

by Alexander eOberc, Brian K. Coombes, Brian K. Coombes, Brian K. Coombes
Published 2015-11-01

High-Throughput Chemical Screening for Inhibitors of Salmonella Pathogenicity Island 2

by Caressa N. Tsai, Brian K. Coombes
Published 2020-09-01

Transcriptional priming of Salmonella Pathogenicity Island-2 precedes cellular invasion.

by Suzanne E Osborne, Brian K Coombes
Published 2011-01-01

Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli.

by Dustin J Little, Brian K Coombes
Published 2018-08-01

A fresh look at the type III secretion system: two-step model of effector translocation in pathogenic bacteria

by Brian K. Coombes, Ana Victoria Pilar
Published 2011-05-01

The evolution of virulence in non-O157 Shiga toxin-producing Escherichia coli

by Brian K. Coombes, Brian K. Coombes, Matthew W. Gilmour, Matthew W. Gilmour, Chelsey D. Goodman
Published 2011-04-01

Crossing the line: selection and evolution of virulence traits.

by Nat F Brown, Mark E Wickham, Brian K Coombes, B Brett Finlay
Published 2006-05-01

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

by N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes
Published 2021-05-01

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome

by Bushra Ilyas, Bushra Ilyas, Caressa N. Tsai, Caressa N. Tsai, Brian K. Coombes
Published 2017-09-01

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.

by Cherrie L Small, Lydia Xing, Joseph B McPhee, Hong T Law, Brian K Coombes
Published 2016-10-01

Correction: Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.

by Cherrie L Small, Lydia Xing, Joseph B McPhee, Hong T Law, Brian K Coombes
Published 2018-04-01

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling.

by Ali A Ashkar, Karen L Mossman, Brian K Coombes, Carlton L Gyles, Randy Mackenzie
Published 2008-12-01

CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling.

by Sarah A Reid-Yu, Brian R Tuinema, Cherrie N Small, Lydia Xing, Brian K Coombes
Published 2015-02-01

Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system.

by Ana M Tomljenovic-Berube, David T Mulder, Matthew D Whiteside, Fiona S L Brinkman, Brian K Coombes
Published 2010-03-01

GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1.

by Ana Victoria C Pilar, Sarah A Reid-Yu, Colin A Cooper, David T Mulder, Brian K Coombes
Published 2012-01-01

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine.

by Nat F Brown, Bruce A Vallance, Brian K Coombes, Yanet Valdez, Bryan A Coburn, B Brett Finlay
Published 2005-11-01

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

by Wael Elhenawy, Sarah Hordienko, Steven Gould, Alexander M. Oberc, Caressa N. Tsai, Troy P. Hubbard, Matthew K. Waldor, Brian K. Coombes
Published 2021-04-01

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

by Craig R. MacNair, Jonathan M. Stokes, Lindsey A. Carfrae, Aline A. Fiebig-Comyn, Brian K. Coombes, Michael R. Mulvey, Eric D. Brown
Published 2018-01-01

Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host.

by Colin A Cooper, Kun Zhang, Sara N Andres, Yuan Fang, Natalia A Kaniuk, Mandy Hannemann, John H Brumell, Leonard J Foster, Murray S Junop, Brian K Coombes
Published 2010-02-01

The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella.

by Deyanira Pérez-Morales, María M Banda, N Y Elizabeth Chau, Heladia Salgado, Irma Martínez-Flores, J Antonio Ibarra, Bushra Ilyas, Brian K Coombes, Víctor H Bustamante
Published 2017-07-01