TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

by Nikolaos Doumpas, Simon Söderholm, Smarth Narula, Steven Moreira, Bradley W. Doble, Claudio Cantù, Konrad Basler
Published 2021-09-01

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.

by Sujeivan Mahendram, Kevin F Kelly, Sabrina Paez-Parent, Sharmeen Mahmood, Enio Polena, Austin J Cooney, Bradley W Doble
Published 2013-01-01

The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin

by Tamara Holowacz, Tania O. Alexson, Brenda L. Coles, Bradley W. Doble, Kevin F. Kelly, James R. Woodgett, Derek Van Der Kooy
Published 2013-06-01

Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways

by Colleen M Bartman, Jennifer eEgelston, Sravya eKattula, Leigh C Zeidner, Anthony eD'Ippolito, Bradley W Doble, Christopher J Phiel
Published 2014-08-01

A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs

by Steven Moreira, Enio Polena, Victor Gordon, Solen Abdulla, Sujeivan Mahendram, Jiayi Cao, Alexandre Blais, Geoffrey A. Wood, Anna Dvorkin-Gheva, Bradley W. Doble
Published 2017-09-01

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

by Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W Doble, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Morris F White, Ernesto Bernal-Mizrachi, James R Woodgett, M Alan Permutt
Published 2008-02-01

Wnt activation as a therapeutic strategy in medulloblastoma

by Branavan Manoranjan, Chitra Venugopal, David Bakhshinyan, Ashley A. Adile, Laura Richards, Michelle M. Kameda-Smith, Owen Whitley, Anna Dvorkin-Gheva, Minomi Subapanditha, Neil Savage, Nazanin Tatari, Dillon McKenna, Blessing Bassey-Archibong, Neil Winegarden, Robin Hallett, John P. Provias, Blake Yarascavitch, Olufemi Ajani, Adam Fleming, Gary D. Bader, Trevor J. Pugh, Bradley W. Doble, Sheila K. Singh
Published 2020-08-01