SAMHD1 Functions and Human Diseases

by Si’Ana A. Coggins, Bijan Mahboubi, Raymond F. Schinazi, Baek Kim
Published 2020-03-01

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection

by Timothy Plitnik, Mark E. Sharkey, Bijan Mahboubi, Baek Kim, Mario Stevenson
Published 2018-12-01

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

by Bijan Mahboubi, Christina Gavegnano, Dong-Hyun Kim, Raymond F. Schinazi, Baek Kim
Published 2018-10-01

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.

by Tatsuya Maehigashi, Seohyun Ahn, Uk-Il Kim, Jared Lindenberger, Adrian Oo, Pratibha C Koneru, Bijan Mahboubi, Alan N Engelman, Mamuka Kvaratskhelia, Kyungjin Kim, Baek Kim
Published 2021-07-01

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

by Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Published 2018-06-01

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

by Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Published 2021-07-01