Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart.

by Karpagam Aravindhan, Weike Bao, Mark R Harpel, Robert N Willette, John J Lepore, Beat M Jucker
Published 2015-01-01

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

by Karpagam Aravindhan, Christine L. Webb, Michael Jaye, Avijit Ghosh, Robert N. Willette, N. John DiNardo, Beat M. Jucker
Published 2006-06-01

Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency.

by Weike Bao, Karpagam Aravindhan, Hasan Alsaid, Thimmaiah Chendrimada, Matthew Szapacs, David R Citerone, Mark R Harpel, Robert N Willette, John J Lepore, Beat M Jucker
Published 2011-01-01

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.

by Feby Savira, Longxing Cao, Ian Wang, Wendi Yang, Kevin Huang, Yue Hua, Beat M Jucker, Robert N Willette, Li Huang, Henry Krum, Zhiliang Li, Qiang Fu, Bing Hui Wang
Published 2017-01-01

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing m...

by Hasan Alsaid, Tinamarie Skedzielewski, Mary V Rambo, Kristen Hunsinger, Bao Hoang, William Fieles, Edward R Long, James Tunstead, Danielle J Vugts, Matthew Cleveland, Neil Clarke, Christopher Matheny, Beat M Jucker
Published 2017-01-01

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

by Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Published 2018-01-01

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress

by Melissa H Costell, Nicolas eAncellin, Roberta E Bernard, Shufang eZhao, John J Upson, Lisa A Morgan, Kristeen eHauk, Alan R Olzinski, Victoria L T Ballard, Kenny eHerry, Pascal eGrondin, Nerina eDodic, Olivier eMirguet, Anne eBouillot, Francoise eGellibert, Robert W Coatney, John J Lepore, Beat M. Jucker, Larry J Jolivette, Robert N Willette, Christine G Schnackenberg, David J Behm
Published 2012-07-01