Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

by Sandra M. McLachlan, Basil Rapoport
Published 2017-12-01

Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor.

by Chun-Rong Chen, Larry M Salazar, Sandra M McLachlan, Basil Rapoport
Published 2012-01-01

Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.

by Sandra M McLachlan, Holly A Aliesky, Chun-Rong Chen, Gao Chong, Basil Rapoport
Published 2012-01-01

Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.

by Sandra M McLachlan, Holly A Aliesky, Chun-Rong Chen, Robert W Williams, Basil Rapoport
Published 2011-01-01

Mechanisms of Autoantibody-Induced Pathology

by Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Frank Leypoldt, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Alan Verkman, Rudolf A. Manz, Falk Nimmerjahn
Published 2017-05-01