Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016

by Susann Schröder, Matthias Scheunemann, Barbara Wenzel, Peter Brust
Published 2021-04-01

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012

by Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Matthias Scheunemann, Peter Brust
Published 2016-05-01

Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emiss...

by Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Ute Egerland, Mathias Kranz, Matthias Scheunemann, Norbert Höfgen, Jörg Steinbach, Peter Brust
Published 2015-05-01

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tom...

by Rien Ritawidya, Barbara Wenzel, Rodrigo Teodoro, Magali Toussaint, Mathias Kranz, Winnie Deuther-Conrad, Sladjana Dukic-Stefanovic, Friedrich-Alexander Ludwig, Matthias Scheunemann, Peter Brust
Published 2019-11-01

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

by Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Mathias Kranz, Matthias Scheunemann, Ute Egerland, Norbert Höfgen, Detlef Briel, Jörg Steinbach, Peter Brust
Published 2018-03-01

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A_2B Receptor Binding Affinity

by Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel
Published 2021-05-01

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain

by Jianrong Liu, Barbara Wenzel, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Susann Schröder, Jean-Michel Chezal, Emmanuel Moreau, Peter Brust, Aurélie Maisonial-Besset
Published 2016-04-01

Preclinical Evaluation of [¹⁸F]FACH in Healthy Mice and Piglets: An ¹⁸F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET

by Daniel Gündel, Masoud Sadeghzadeh, Winnie Deuther-Conrad, Barbara Wenzel, Paul Cumming, Magali Toussaint, Friedrich-Alexander Ludwig, Rareş-Petru Moldovan, Mathias Kranz, Rodrigo Teodoro, Bernhard Sattler, Osama Sabri, Peter Brust
Published 2021-02-01

Preclinical Incorporation Dosimetry of [¹⁸F]FACH—A Novel ¹⁸F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET

by Bernhard Sattler, Mathias Kranz, Barbara Wenzel, Nalin T. Jain, Rareş-Petru Moldovan, Magali Toussaint, Winnie Deuther-Conrad, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Tatjana Sattler, Masoud Sadeghzadeh, Osama Sabri, Peter Brust
Published 2020-04-01

Development of a Radiofluorinated Adenosine A_2B Receptor Antagonist as Potential Ligand for PET Imaging

by Marcel Lindemann, Rareş-Petru Moldovan, Sonja Hinz, Winnie Deuther-Conrad, Daniel Gündel, Sladjana Dukic-Stefanovic, Magali Toussaint, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel
Published 2020-04-01

PET Imaging of the Adenosine A_2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [¹⁸F]FESCH Synthesized by a Simplified Two-Step One-Po...

by Susann Schröder, Thu Hang Lai, Magali Toussaint, Mathias Kranz, Alexandra Chovsepian, Qi Shang, Sladjana Dukić-Stefanović, Winnie Deuther-Conrad, Rodrigo Teodoro, Barbara Wenzel, Rareş-Petru Moldovan, Francisco Pan-Montojo, Peter Brust
Published 2020-04-01

Development of Novel Analogs of the Monocarboxylate Transporter Ligand FACH and Biological Validation of One Potential Radiotracer for Positron Emission Tomography (PET) Imaging

by Masoud Sadeghzadeh, Barbara Wenzel, Daniel Gündel, Winnie Deuther-Conrad, Magali Toussaint, Rareş-Petru Moldovan, Steffen Fischer, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Gerrit Schüürmann, Venkatram R. Mereddy, Lester R. Drewes, Peter Brust
Published 2020-05-01

A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand

by Rodrigo Teodoro, Matthias Scheunemann, Winnie Deuther-Conrad, Barbara Wenzel, Francesca Maria Fasoli, Cecilia Gotti, Mathias Kranz, Cornelius K. Donat, Marianne Patt, Ansel Hillmer, Ming-Qiang Zheng, Dan Peters, Jörg Steinbach, Osama Sabri, Yiyun Huang, Peter Brust
Published 2015-10-01