Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum.

by Ingrid B Müller, Fang Wu, Bärbel Bergmann, Julia Knöckel, Rolf D Walter, Heinz Gehring, Carsten Wrenger
Published 2009-01-01

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity.

by Paolo Mesén-Ramírez, Ferdinand Reinsch, Alexandra Blancke Soares, Bärbel Bergmann, Ann-Katrin Ullrich, Stefan Tenzer, Tobias Spielmann
Published 2016-05-01

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale.

by André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz
Published 2017-02-01

The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.

by Ingrid B Müller, Bärbel Bergmann, Matthew R Groves, Isabel Couto, Leonard Amaral, Tadhg P Begley, Rolf D Walter, Carsten Wrenger
Published 2009-11-01

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites.

by Paolo Mesén-Ramírez, Bärbel Bergmann, Thuy Tuyen Tran, Matthias Garten, Jan Stäcker, Isabel Naranjo-Prado, Katharina Höhn, Joshua Zimmerberg, Tobias Spielmann
Published 2019-09-01