Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck

by Greg M Delgoffe, Kristin DePeaux, Angen Liu, Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle
Published 2021-05-01

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

by Min Yang, Wenwen Du, Lixian Yi, Shaoxian Wu, Chunyan He, Wensi Zhai, Cuihua Yue, Runzi Sun, Ashley V. Menk, Greg M. Delgoffe, Jingting Jiang, Binfeng Lu
Published 2020-01-01

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

by Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Published 2018-02-01

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

by Dana M. Previte, Christina P. Martins, Erin C. O’Connor, Meghan L. Marre, Gina M. Coudriet, Noah W. Beck, Ashley V. Menk, Rebecca H. Wright, Hubert M. Tse, Greg M. Delgoffe, Jon D. Piganelli
Published 2019-04-01

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

by Alicia R. Watson, Alicia R. Watson, Helong Dai, Helong Dai, Yawen Zheng, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Greg M. Delgoffe, Angus W. Thomson, Angus W. Thomson
Published 2019-07-01