Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

by Asako Otomo, Lei Pan, Shinji Hadano
Published 2012-01-01

Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice.

by Lei Pan, Yasuhiro Yoshii, Asako Otomo, Haruko Ogawa, Yasuo Iwasaki, Hui-Fang Shang, Shinji Hadano
Published 2012-01-01

GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.

by Kaori Suyama, Masahiko Watanabe, Kou Sakabe, Asako Otomo, Yoshinori Okada, Hayato Terayama, Takeshi Imai, Joji Mochida
Published 2014-01-01

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.

by Shinji Hadano, Asako Otomo, Ryota Kunita, Kyoko Suzuki-Utsunomiya, Akira Akatsuka, Masato Koike, Masashi Aoki, Yasuo Uchiyama, Yasuto Itoyama, Joh-E Ikeda
Published 2010-03-01

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

by Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Ryohei Shirakawa, Hiroaki Adachi, Masashi Aoki, Gen Sobue, Hui-Fang Shang, Shinji Hadano
Published 2018-05-01

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

by Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, YongPing Chen, Yutaro Hama, Kai Sato, XuePing Chen, Toshiyasu Suzuki, Hui-Fang Shang, Shinji Hadano
Published 2021-03-01

Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B.

by Hideki Hayashi, Ting Wang, Masayuki Tanaka, Sanae Ogiwara, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yumi Iida, Ayaka Nakamura, Ayumi Sasaki, Shunji Amano, Kazuhiro Yoshida, Asako Otomo, Masato Ohtsuka, Shinji Hadano
Published 2020-01-01

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

by Akira Oka, Atsushi Takagi, Etsuko Komiyama, Nagisa Yoshihara, Shuhei Mano, Kazuyoshi Hosomichi, Shingo Suzuki, Yuko Haida, Nami Motosugi, Tomomi Hatanaka, Minoru Kimura, Mahoko Takahashi Ueda, So Nakagawa, Hiromi Miura, Masato Ohtsuka, Masayuki Tanaka, Tomoyoshi Komiyama, Asako Otomo, Shinji Hadano, Tomotaka Mabuchi, Stephan Beck, Hidetoshi Inoko, Shigaku Ikeda
Published 2020-07-01