Chimeric antigen receptorâengineered T cells as oncolytic virus carriers

by Heather VanSeggelen, Daniela GM Tantalo, Arya Afsahi, Joanne A Hammill, Jonathan L Bramson
Published 2015-01-01

94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation

by Vivian Lau, Duane Moogk, Joanne Hammill, Jonathan Bramson, Arya Afsahi, Anna Dvorkin-Gheva, Ksenia Bezverbnaya
Published 2020-11-01

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

by Christopher W. Helsen, Joanne A. Hammill, Vivian W. C. Lau, Kenneth A. Mwawasi, Arya Afsahi, Ksenia Bezverbnaya, Lisa Newhook, Danielle L. Hayes, Craig Aarts, Bojana Bojovic, Galina F. Denisova, Jacek M. Kwiecien, Ian Brain, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Published 2018-08-01