Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1.

by Shuo Wang, Jennifer F Raven, Joan E Durbin, Antonis E Koromilas
Published 2008-01-01

Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.

by Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Shuo Wang, Ramzi Melhem, Antonis E Koromilas, Fawaz G Haj
Published 2012-01-01

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

by Cedric Darini, Nour Ghaddar, Catherine Chabot, Gloria Assaker, Siham Sabri, Shuo Wang, Jothilatha Krishnamoorthy, Marguerite Buchanan, Adriana Aguilar-Mahecha, Bassam Abdulkarim, Jean Deschenes, Jose Torres, Josie Ursini-Siegel, Mark Basik, Antonis E. Koromilas
Published 2019-05-01

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

by Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt, Steven Hébert, Stephanie Totten, Nicolas De Jay, Maria Carolina Festa, Yoon Kow Young, Young Kyuen Im, Tony Pawson, Antonis E. Koromilas, William J. Muller, Koren K. Mann, Claudia L. Kleinman, Josie Ursini-Siegel
Published 2017-03-01

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

by Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, Ivan Topisirovic
Published 2016-04-01

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

by Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Published 2021-07-01

Characterization of the roles of the transcription factor Stat1 and the translation initiation factor eIF2alpha kinases in cell cycle control and tumourigenesis

by Raven, Jennifer
Published 2009

The eIF2alpha phosphorylation pathway as a novel component of PI3K signaling with implications in tumor treatment

by Mounir, Zineb
Published 2011

Phosphorylation of eukaryotic initiation factor 2-alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency

by Muaddi, Hala
Published 2010

Characterization of the eIF2alpha kinase PKR in regulating the Hypoxia Inducible Factor 1 alpha and the development of novel in vivo and in vitro experimental models to study the b...

by Papadakis, Andreas
Published 2012