Sphingosine 1-Phosphate in Renal Diseases

by Alexander Koch, Josef Pfeilschifter, Andrea Huwiler
Published 2013-05-01

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

by Sandra Beyer, Stephanie Schwalm, Josef Pfeilschifter, Andrea Huwiler
Published 2018-07-01

Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

by Nataliya Kotelevets, Doriano Fabbro, Andrea Huwiler, Uwe Zangemeister-Wittke
Published 2013-01-01

Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis.

by Nataliya Kotelevets, Doriano Fabbro, Andrea Huwiler, Uwe Zangemeister-Wittke
Published 2013-01-01

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.

by Nataliya Kotelevets, Doriano Fabbro, Andrea Huwiler, Uwe Zangemeister-Wittke
Published 2012-01-01

S1P Stimulates Erythropoietin Production in Mouse Renal Interstitial Fibroblasts by S1P₁ and S1P₃ Receptor Activation and HIF-2α Stabilization

by Redona Hafizi, Faik Imeri, Roland H. Wenger, Andrea Huwiler
Published 2021-08-01

Small Peptides Able to Suppress Prostaglandin E2 Generation in Renal Mesangial Cells

by Sofia Vasilakaki, Oleksandr Pastukhov, Thomas Mavromoustakos, Andrea Huwiler, George Kokotos
Published 2018-01-01

Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation

by Cuiyan Xin, Shuyu Ren, Wolfgang Eberhardt, Josef Pfeilschifter, Andrea Huwiler
Published 2007-09-01

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

by Stephanie Schwalm, Martin Erhardt, Isolde Römer, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler
Published 2020-02-01

Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts

by Oleksandr Pastukhov, Stephanie Schwalm, Isolde Römer, Uwe Zangemeister-Wittke, Josef Pfeilschifter, Andrea Huwiler
Published 2014-06-01

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge

by Bisera Stepanovska, Antonia I. Lange, Stephanie Schwalm, Josef Pfeilschifter, Sina M. Coldewey, Andrea Huwiler
Published 2020-02-01

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P₁ Agonist and Functional Antagonist Potency In Vitro and In Vivo

by Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea Huwiler
Published 2021-08-01

A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders.

by Andrea Huwiler, Florence Bourquin, Nataliya Kotelevets, Oleksandr Pastukhov, Guido Capitani, Markus G Grütter, Uwe Zangemeister-Wittke
Published 2011-01-01

Morpholino Analogues of Fingolimod as Novel and Selective S1P₁ Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis

by Bisera Stepanovska, Aleksandra Zivkovic, Gaby Enzmann, Silvia Tietz, Thomas Homann, Burkhard Kleuser, Britta Engelhardt, Holger Stark, Andrea Huwiler
Published 2020-09-01

α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E₂ (PGE₂) in Rat Mesangial Cells

by Anastasia Psarra, Maria A. Theodoropoulou, Martin Erhardt, Marina Mertiri, Christiana Mantzourani, Sofia Vasilakaki, Victoria Magrioti, Andrea Huwiler, George Kokotos
Published 2021-02-01

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

by Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler
Published 2018-05-01

Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.

by Shunya Kondo, Alessia Bottos, Jeremy C Allegood, Regis Masson, Francisca G Maurer, Christel Genoud, Patrick Kaeser, Andrea Huwiler, Masato Murakami, Sarah Spiegel, Nancy E Hynes
Published 2014-01-01

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

by Louise Tzung-Harn Hsieh, Madalina-Viviana Nastase, Heiko Roedig, Jinyang Zeng-Brouwers, Chiara Poluzzi, Stephanie Schwalm, Christian Fork, Claudia Tredup, Ralf P. Brandes, Malgorzata Wygrecka, Andrea Huwiler, Josef Pfeilschifter, Liliana Schaefer
Published 2017-03-01