Epigallocathechin-O-3-Gallate Inhibits Trypanothione Reductase of Leishmania infantum, Causing Alterations in Redox Balance and Leading to Parasite Death

by Job D. F. Inacio, Myslene S. Fonseca, Gabriel Limaverde-Sousa, Ana M. Tomas, Ana M. Tomas, Helena Castro, Elmo E. Almeida-Amaral
Published 2021-03-01

Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity.

by Helena Castro, Susana Romao, Sandra Carvalho, Filipa Teixeira, Carla Sousa, Ana M Tomás
Published 2010-09-01

Development of an automated image analysis protocol for quantification of intracellular forms of Leishmania spp.

by Ana G Gomes-Alves, André F Maia, Tânia Cruz, Helena Castro, Ana M Tomás
Published 2018-01-01

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum

by Verónica Gómez Pérez, Raquel García-Hernandez, Victoriano Corpas-López, Ana M. Tomás, Joaquina Martín-Sanchez, Santiago Castanys, Francisco Gamarro
Published 2016-08-01

Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents

by Helena Castro, Tânia Cruz, Patrícia de Aguiar Amaral, Paula da Silva Cardoso, Ahmed Alsaffar, Patrick Farrell, Ana M. Tomás, James W. Barlow
Published 2020-03-01

Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.

by Helena Castro, Filipa Teixeira, Susana Romao, Mariana Santos, Tânia Cruz, Manuela Flórido, Rui Appelberg, Pedro Oliveira, Frederico Ferreira-da-Silva, Ana M Tomás
Published 2011-10-01

In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum

by Strahinja Stevanović, Andrej Perdih, Milan Senćanski, Sanja Glišić, Margarida Duarte, Ana M. Tomás, Filipa V. Sena, Filipe M. Sousa, Manuela M. Pereira, Tom Solmajer
Published 2018-03-01

Chaperone activation and client binding of a 2-cysteine peroxiredoxin

by Filipa Teixeira, Eric Tse, Helena Castro, Karl A. T. Makepeace, Ben A. Meinen, Christoph H. Borchers, Leslie B. Poole, James C. Bardwell, Ana M. Tomás, Daniel R. Southworth, Ursula Jakob
Published 2019-02-01