Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

by Michael Seimetz, Nirmal Parajuli, Alexandra Pichl, Mariola Bednorz, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly, Werner Seeger, Friedrich Grimminger, Norbert Weissmann
Published 2015-01-01

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD

by Juliana Heidler, Athanasios Fysikopoulos, Frank Wempe, Michael Seimetz, Thorsten Bangsow, Ana Tomasovic, Florian Veit, Susan Scheibe, Alexandra Pichl, Friederike Weisel, K. C. Kent Lloyd, Peter Jaksch, Walter Klepetko, Norbert Weissmann, Harald von Melchner
Published 2013-11-01