Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome

by Larisa V. Lysenko, Jeesun Kim, Francisco Madamba, Anna A. Tyrtyshnaia, Aarti Ruparelia, Alexander M. Kleschevnikov
Published 2018-07-01

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

by Alexander M. Kleschevnikov, Jessica Yu, Jeesun Kim, Larisa V. Lysenko, Zheng Zeng, Y. Eugene Yu, William C. Mobley
Published 2017-07-01

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

by Alexander M. Kleschevnikov, Pavel V. Belichenko, Jessica Gall, Lizzy George, Rachel Nosheny, Michael T. Maloney, Ahmad Salehi, William C. Mobley
Published 2012-02-01

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

by Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley
Published 2015-01-01

Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome.

by Larisa V Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A Kohnz, Francisco Madamba, Gabriel M Simon, Natalia E Kleschevnikova, Daniel K Nomura, R Alan B Ezekowitz, Alexander M Kleschevnikov
Published 2014-01-01

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.

by Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Mobley
Published 2016-01-01