Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

by Felipe T. Lee-Montiel, Alexander Laemmle, Alexander Laemmle, Verena Charwat, Laure Dumont, Caleb S. Lee, Nathaniel Huebsch, Hideaki Okochi, Matthew J. Hancock, Brian Siemons, Steven C. Boggess, Ishan Goswami, Evan W. Miller, Holger Willenbring, Kevin E. Healy
Published 2021-05-01

Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD).

by Alexander Laemmle, Renata C Gallagher, Adrian Keogh, Tamar Stricker, Matthias Gautschi, Jean-Marc Nuoffer, Matthias R Baumgartner, Johannes Häberle
Published 2016-01-01

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.

by Alexander Laemmle, Antje Lechleiter, Vincent Roh, Christa Schwarz, Simone Portmann, Cynthia Furer, Adrian Keogh, Mario P Tschan, Daniel Candinas, Stephan A Vorburger, Deborah Stroka
Published 2012-01-01