Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

by Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell
Published 2018-09-01

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

by Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Stephan Frank, Takashi Saito, Takaomi C. Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti
Published 2021-08-01

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

by Peer-Hendrik Kuhn, Alessio Vittorio Colombo, Benjamin Schusser, Daniela Dreymueller, Sebastian Wetzel, Ute Schepers, Julia Herber, Andreas Ludwig, Elisabeth Kremmer, Dirk Montag, Ulrike Müller, Michaela Schweizer, Paul Saftig, Stefan Bräse, Stefan F Lichtenthaler
Published 2016-01-01

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

by Laura Sebastian Monasor, Stephan A Müller, Alessio Vittorio Colombo, Gaye Tanrioever, Jasmin König, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C Saido, Jochen Herms, Michael Willem, Christian Haass, Stefan F Lichtenthaler, Sabina Tahirovic
Published 2020-06-01

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

by Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio‐Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl‐Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass
Published 2019-06-01

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

by Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Published 2021-04-01