Full atomistic model of prion structure and conversion.

by Giovanni Spagnolli, Marta Rigoli, Simone Orioli, Alejandro M Sevillano, Pietro Faccioli, Holger Wille, Emiliano Biasini, Jesús R Requena
Published 2019-07-01

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

by Julia A. Callender, Alejandro M. Sevillano, Katrin Soldau, Timothy D. Kurt, Taylor Schumann, Donald P. Pizzo, Hermann Altmeppen, Markus Glatzel, Jeffrey D. Esko, Christina J. Sigurdson
Published 2020-08-01

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

by Ester Vázquez-Fernández, Matthijn R Vos, Pavel Afanasyev, Lino Cebey, Alejandro M Sevillano, Enric Vidal, Isaac Rosa, Ludovic Renault, Adriana Ramos, Peter J Peters, José Jesús Fernández, Marin van Heel, Howard S Young, Jesús R Requena, Holger Wille
Published 2016-09-01

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

by Alejandro M Sevillano, Natalia Fernández-Borges, Neelam Younas, Fei Wang, Saioa R Elezgarai, Susana Bravo, Ester Vázquez-Fernández, Isaac Rosa, Hasier Eraña, David Gil, Sonia Veiga, Enric Vidal, Melissa L Erickson-Beltran, Esteban Guitián, Christopher J Silva, Romolo Nonno, Jiyan Ma, Joaquín Castilla, Jesús R Requena
Published 2018-01-01