Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease

by Mary Carmen Vázquez, Elisa Balboa, Alejandra R. Alvarez, Silvana Zanlungo
Published 2012-01-01

Activation of the neuronal c-Abl tyrosine kinase by amyloid-β-peptide and reactive oxygen species

by Alejandra R. Alvarez, Pablo C. Sandoval, Nancy R. Leal, Paula U. Castro, Kenneth S. Kosik
Published 2004-11-01

c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation

by Fabián Montecino, Natalia González, Natasha Blanco, Manuel J. Ramírez, Adrián González-Martín, Alejandra R. Alvarez, Hugo Olguín
Published 2021-03-01

c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers

by Daniela A. Gutierrez, Lina M. Vargas, América Chandia-Cristi, Catalina de la Fuente, Nancy Leal, Alejandra R. Alvarez
Published 2019-11-01

Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response.

by Andrea V Gómez, Gonzalo Córdova, Roberto Munita, Guillermo E Parada, Álvaro P Barrios, Gonzalo I Cancino, Alejandra R Álvarez, María E Andrés
Published 2015-01-01

Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice

by Tamara Marín, Pablo Contreras, Juan Francisco Castro, David Chamorro, Elisa Balboa, Mònica Bosch-Morató, Francisco J. Muñoz, Alejandra R. Alvarez, Silvana Zanlungo
Published 2014-07-01

EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

by Lina M Vargas, Nancy Leal, Lisbell D Estrada, Adrian González, Felipe Serrano, Katherine Araya, Katia Gysling, Nibaldo C Inestrosa, Elena B Pasquale, Alejandra R Alvarez
Published 2014-01-01

Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons

by Andres Klein, Carola Maldonado, Lina M. Vargas, Marcela Gonzalez, Fermín Robledo, Karen Perez de Arce, Francisco J. Muñoz, Claudio Hetz, Alejandra R. Alvarez, Silvana Zanlungo
Published 2011-01-01

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

by Hideaki Tomita, Francisca Cornejo, Begoña Aranda-Pino, Cameron L. Woodard, Constanza C. Rioseco, Benjamin G. Neel, Alejandra R. Alvarez, David R. Kaplan, Freda D. Miller, Gonzalo I. Cancino
Published 2020-01-01

Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage

by Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Published 2021-08-01

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

by Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa, Silvana Zanlungo
Published 2017-08-01

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

by Pol Picón-Pagès, Daniela A. Gutiérrez, Alejandro Barranco-Almohalla, Giulia Crepin, Marta Tajes, Gerard ILL-Raga, Francesc X. Guix, Silvia Menéndez, Montserrat Arumí-Uría, Rubén Vicente, Alejandra R. Álvarez, Francisco J. Muñoz
Published 2020-01-01

Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer’s disease

by Francisco Morales-Zavala, Nathalie Casanova-Morales, Raúl B. Gonzalez, América Chandía-Cristi, Lisbell D. Estrada, Ignacio Alvizú, Victor Waselowski, Fanny Guzman, Simón Guerrero, Marisol Oyarzún-Olave, Cristian Rebolledo, Enrique Rodriguez, Julien Armijo, Heman Bhuyan, Mario Favre, Alejandra R. Alvarez, Marcelo J. Kogan, Jerónimo R. Maze
Published 2018-08-01

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

by Pablo S. Contreras, Pablo J. Tapia, Lila González-Hódar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis Martinez, Elisa Balboa, Juan Castro, Nancy Leal, Frances M. Platt, Andrzej Sobota, Dominic Winter, Andrés D. Klein, Diego L. Medina, Andrea Ballabio, Alejandra R. Alvarez, Silvana Zanlungo
Published 2020-11-01