Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo

by Jyothsna Visweswaraiah, Alan G Hinnebusch
Published 2017-02-01

Accumulation of a threonine biosynthetic intermediate attenuates general amino acid control by accelerating degradation of Gcn4 via Pho85 and Cdk8.

by Yashpal Rawal, Hongfang Qiu, Alan G Hinnebusch
Published 2014-07-01

Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner

by Neha Gupta, Jon R Lorsch, Alan G Hinnebusch
Published 2018-10-01

Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.

by Sebastien Lageix, Jinwei Zhang, Stefan Rothenburg, Alan G Hinnebusch
Published 2015-02-01

Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

by Suna Gulay, Neha Gupta, Jon R Lorsch, Alan G Hinnebusch
Published 2020-05-01

The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

by Jyothsna Visweswaraiah, Yvette Pittman, Thomas E Dever, Alan G Hinnebusch
Published 2015-07-01

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells.

by Sebastien Lageix, Stefan Rothenburg, Thomas E Dever, Alan G Hinnebusch
Published 2014-05-01

Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

by Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, Alan G Hinnebusch
Published 2018-12-01

Correction: Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

by Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, Alan G Hinnebusch
Published 2019-07-01

Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

by Swati Gaikwad, Fardin Ghobakhlou, David J Young, Jyothsna Visweswaraiah, Hongen Zhang, Alan G Hinnebusch
Published 2021-03-01

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

by Paul Yourik, Colin Echeverría Aitken, Fujun Zhou, Neha Gupta, Alan G Hinnebusch, Jon R Lorsch
Published 2017-11-01

Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae

by Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch, Jon R. Lorsch
Published 2019-12-01

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

by Colin Echeverría Aitken, Petra Beznosková, Vladislava Vlčkova, Wen-Ling Chiu, Fujun Zhou, Leoš Shivaya Valášek, Alan G Hinnebusch, Jon R Lorsch
Published 2016-10-01

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

by Jose Luis Llácer, Tanweer Hussain, Adesh K Saini, Jagpreet Singh Nanda, Sukhvir Kaur, Yuliya Gordiyenko, Rakesh Kumar, Alan G Hinnebusch, Jon R Lorsch, V Ramakrishnan
Published 2018-11-01

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

by Pilar Martin-Marcos, Fujun Zhou, Charm Karunasiri, Fan Zhang, Jinsheng Dong, Jagpreet Nanda, Shardul D Kulkarni, Neelam Dabas Sen, Mercedes Tamame, Michael Zeschnigk, Jon R Lorsch, Alan G Hinnebusch
Published 2017-12-01

The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

by Rafael E. Luna, Haribabu Arthanari, Hiroyuki Hiraishi, Jagpreet Nanda, Pilar Martin-Marcos, Michelle A. Markus, Barak Akabayov, Alexander G. Milbradt, Lunet E. Luna, Hee-Chan Seo, Sven G. Hyberts, Amr Fahmy, Mikhail Reibarkh, David Miles, Patrick R. Hagner, Elizabeth M. O'Day, Tingfang Yi, Assen Marintchev, Alan G. Hinnebusch, Jon R. Lorsch, Katsura Asano, Gerhard Wagner
Published 2012-06-01

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

by Eiji Obayashi, Rafael E. Luna, Takashi Nagata, Pilar Martin-Marcos, Hiroyuki Hiraishi, Chingakham Ranjit Singh, Jan Peter Erzberger, Fan Zhang, Haribabu Arthanari, Jacob Morris, Riccardo Pellarin, Chelsea Moore, Ian Harmon, Evangelos Papadopoulos, Hisashi Yoshida, Mahmoud L. Nasr, Satoru Unzai, Brytteny Thompson, Eric Aube, Samantha Hustak, Florian Stengel, Eddie Dagraca, Asokan Ananbandam, Philip Gao, Takeshi Urano, Alan G. Hinnebusch, Gerhard Wagner, Katsura Asano
Published 2017-03-01