Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

by S. Lindsey eDavis, S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, Todd M. Pitts, John J. Tentler, John J. Tentler, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, John J. Arcaroli, Wells A. Messersmith, Wells A. Messersmith, Aik Choon eTan, Aik Choon eTan, S. Gail eEckhardt, S. Gail eEckhardt
Published 2015-06-01

Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

by Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Todd M Pitts, Aik-Choon eTan, Kelly eMcPhillips, Mark eWest, Daniel L Gustafson, Charles eHalsey, Leslie eNguyen, Nathan V Lee, Julie LC Kan, Brion William Murray, S. Gail eEckhardt
Published 2013-03-01

Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

by Todd M Pitts, Gillian N Kulikowski, Aik-Choon eTan, Brion William Murray, John J Arcaroli, John J Tentler, Anna eSpreafico, Heather M Selby, Maria I Kachaeva, Kelly L McPhillips, Blair C Britt, Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Wells A Messersmith, Marileila eVarella-Garcia, S. Gail eEckhardt
Published 2013-03-01