Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

by Bridgette M. Cumming, Hayden T. Pacl, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn
Published 2020-09-01

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

by Md. Aejazur Rahman, Joel N. Glasgow, Sajid Nadeem, Vineel P. Reddy, Ritesh R. Sevalkar, Jack R. Lancaster, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn
Published 2020-11-01

Heme Oxygenase-1 as a Pharmacological Target for Host-Directed Therapy to Limit Tuberculosis Associated Immunopathology

by Krishna C. Chinta, Hayden T. Pacl, Anupam Agarwal, Adrie J. C. Steyn
Published 2021-01-01

<i>Mycobacterium tuberculosis</i>-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring

by Wadzanai Manjeese, Nontobeko E. Mvubu, Adrie J. C. Steyn, Thabisile Mpofana
Published 2021-04-01

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection

by Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn
Published 2018-05-01

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.

by Amit Singh, David K Crossman, Deborah Mai, Loni Guidry, Martin I Voskuil, Matthew B Renfrow, Adrie J C Steyn
Published 2009-08-01

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish

by Zhenkang Chen, Yangbo Hu, Bridgette M. Cumming, Pei Lu, Lipeng Feng, Jiaoyu Deng, Adrie J.C. Steyn, Shiyun Chen
Published 2016-08-01

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

by Yi Cai, Eleni Jaecklein, Jared S Mackenzie, Kadamba Papavinasasundaram, Andrew J Olive, Xinchun Chen, Adrie J C Steyn, Christopher M Sassetti
Published 2021-07-01

Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants

by Micah D. Dunlap, Micah D. Dunlap, Oliver A. Prince, Javier Rangel-Moreno, Kimberly A. Thomas, Julia M. Scordo, Jordi B. Torrelles, Jeffery Cox, Adrie J. C. Steyn, Adrie J. C. Steyn, Joaquín Zúñiga, Deepak Kaushal, Deepak Kaushal, Deepak Kaushal, Shabaana A. Khader, Shabaana A. Khader
Published 2020-06-01

Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

by Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn
Published 2017-07-01

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

by Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn
Published 2017-05-01

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

by Dirk A. Lamprecht, Peter M. Finin, Md. Aejazur Rahman, Bridgette M. Cumming, Shannon L. Russell, Surendranadha R. Jonnala, John H. Adamson, Adrie J. C. Steyn
Published 2016-08-01

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

by Shannon L. Russell, Dirk A. Lamprecht, Tawanda Mandizvo, Terrence T. Jones, Vanessa Naidoo, Kelvin W. Addicott, Chivonne Moodley, Bongani Ngcobo, David K. Crossman, Gordon Wells, Adrie J.C. Steyn
Published 2019-12-01

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

by Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole
Published 2018-10-01

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.

by Andréanne Lupien, Caroline Shi-Yan Foo, Svetlana Savina, Anthony Vocat, Jérémie Piton, Natalia Monakhova, Andrej Benjak, Dirk A Lamprecht, Adrie J C Steyn, Kevin Pethe, Vadim A Makarov, Stewart T Cole
Published 2020-01-01

<i>Mycobacterium tuberculosis</i> H₂S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility

by Tafara T. R. Kunota, Md. Aejazur Rahman, Barry E. Truebody, Jared S. Mackenzie, Vikram Saini, Dirk A. Lamprecht, John H. Adamson, Ritesh R. Sevalkar, Jack R. Lancaster, Michael Berney, Joel N. Glasgow, Adrie J. C. Steyn
Published 2021-08-01

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

by Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Published 2020-11-01

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

by Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Published 2020-01-01

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

by Vikram Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht, John H. Adamson, Vineel P. Reddy, Krishna C. Chinta, James H. Mazorodze, Joel N. Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J.C. Steyn
Published 2016-01-01

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

by Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn
Published 2018-11-01