Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

by Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin
Published 2018-08-01

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

by Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin
Published 2019-08-01

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

by Megan E. Meuser, Adel A. Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B. Ward, Simon Cocklin
Published 2019-04-01

Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

by Charles Gotuaco Ang, Erik Carter, Ann Haftl, Shiyu Zhang, Adel A. Rashad, Michele Kutzler, Cameron F. Abrams, Irwin M. Chaiken
Published 2021-06-01

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

by Shiyu Zhang, Andrew P. Holmes, Alexej Dick, Adel A. Rashad, Lucía Enríquez Rodríguez, Gabriela A. Canziani, Michael J. Root, Irwin M. Chaiken
Published 2021-10-01

Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2

by Ahmed Kandeil, Ahmed Mostafa, Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al-Karmalawy, Adel A. Rashad, Ahmed E. Kayed, Azza E. Kayed, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali
Published 2021-06-01

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2

by Ahmed Mostafa, Ahmed Kandeil, Yaseen A. M. M. Elshaier, Omnia Kutkat, Yassmin Moatasim, Adel A. Rashad, Mahmoud Shehata, Mokhtar R. Gomaa, Noura Mahrous, Sara H. Mahmoud, Mohamed GabAllah, Hisham Abbas, Ahmed El Taweel, Ahmed E. Kayed, Mina Nabil Kamel, Mohamed El Sayes, Dina B. Mahmoud, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali
Published 2020-12-01