ADMET prediction Animals Article Binding Sites COX-2 inhibitor Cell Line Cell Survival Chalcones Cyclooxygenase 2 Dinoprostone Dose-Response Relationship, Drug Flavonoids Humans IC50 Intramolecular Oxidoreductases Lipopolysaccharides MTT assay Mice Minor flavonoids Models, Molecular Molecular Structure Murinae Prenylated chalcone Single-crystal XRD Structure-Activity Relationship Suzuki reaction X ray diffraction alkylation animal animal cell