PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

by Anna Maria Cseh, Anna Maria Cseh, Zsolt Fabian, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Aliz Szabo, Aliz Szabo, Krisztian Eros, Krisztian Eros, Krisztian Eros, Maria Eugenia Soriano, Maria Eugenia Soriano, Ferenc Gallyas, Ferenc Gallyas, Ferenc Gallyas, Luca Scorrano, Luca Scorrano, Balazs Sumegi, Balazs Sumegi, Balazs Sumegi
Published 2019-05-01

Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

by Rubén Quintana-Cabrera, Israel Manjarrés-Raza, Carlos Vicente-Gutiérrez, Mauro Corrado, Juan P. Bolaños, Luca Scorrano
Published 2021-05-01

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

by Rubén Quintana-Cabrera, Charlotte Quirin, Christina Glytsou, Mauro Corrado, Andrea Urbani, Anna Pellattiero, Enrique Calvo, Jesús Vázquez, José Antonio Enríquez, Christoph Gerle, María Eugenia Soriano, Paolo Bernardi, Luca Scorrano
Published 2018-08-01

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

by Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Published 2020-08-01

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

by Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza
Published 2019-08-01