human 139 controlled study 115 Humans 108 randomized controlled trial 97 male 95 female 92 Article 83 adult 82 placebo 68 double blind procedure 62 Male 60 Female 56 treatment outcome 45 Double-Blind Method 44 Adult 43 major clinical study 40 middle aged 37 Middle Aged 35 Treatment Outcome 34 aged 33 drug efficacy 32 drug safety 30 clinical trial 27 adolescent 23 young adult 23 Young Adult 22 drug effect 21 Adolescent 20 clinical article 19 multicenter study 19