A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy

by Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Published 2021-11-01

Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

by Zhu Chen, Bin Luo, Tian-Quan Cai, Anil Thankappan, Yiming Xu, Weizhen Wu, Jillian DiMuzio, Traci Lifsted, Marty DiPietro, Jyoti Disa, Bruce Ng, Karen Leander, Seth Clark, Lizbeth Hoos, Yuchen Zhou, Nina Jochnowitz, Christine Jachec, Peter Szczerba, Marian E Gindy, Walter Strapps, Laura Sepp-Lorenzino, Dietmar A Seiffert, Laura Lubbers, Marija Tadin-Strapps
Published 2015-01-01

Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation

by Bruce Ng, Tanesha Cash-Mason, Yi Wang, Jessica Seitzer, Julja Burchard, Duncan Brown, Vadim Dudkin, Joseph Davide, Vasant Jadhav, Laura Sepp-Lorenzino, Pedro J. Cejas
Published 2019-06-01

Utilizing Probiotics for the Prevention and Treatment of Gastrointestinal Diseases

by Erin Milner, Erin Milner, Benjamin Stevens, Martino An, Victoria Lam, Michael Ainsworth, Preston Dihle, Jocelyn Stearns, Andrew Dombrowski, Daniel Rego, Katharine Segars
Published 2021-08-01

Limitations of employing antibody drug conjugates (ADCs) for targeting HIV infected cells as a strategy for hiv cure

by J. Strizki, D. Graham, M. Lu, G. Wu, M. Breslin, N. Davis, E. Escandon, L. Fayadat-Dilman, Y. Zheng, R. Barnard, R. Garbaccio, A. Manibusan, S. Bhowmik, D. Gately, Y. Sun, D. Gorman
Published 2015-12-01

Treatment of SHIV-infected, ART-suppressed rhesus macaques with bispecific HIVxCD3 DART® molecules

by Daniel M. Gorman, Ming-Tain Lai, Carolyn McHale, Meiqing Lu, Don Graham, Julie Strizki, Yanyan Zheng, Shirley Ma, Soha Moltagh, Marc Bailly, SuChun Hseih, Glareh Azadi, Yaoli Song, Fernando Ugarte, Romina Riener, Wendy Blumenschein, Daria Hazuda, Jeffery Nordstrom, Bonnie Howell
Published 2019-12-01

Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process

by Bennett Ma, Gregg Wesolowski, Bin Luo, Traci Lifsted, Keith Wessner, Gary Adamson, Helmut Glantschnig, Laura S Lubbers
Published 2019-01-01

Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

by Erin Milner, Michael Ainsworth, Matthew McDonough, Benjamin Stevens, Johannah Buehrer, Richard Delzell, Cameron Wilson, Jason Barnhill
Published 2020-12-01

Noble Metal Composite Porous Silk Fibroin Aerogel Fibers

by Alexander N. Mitropoulos, F. John Burpo, Chi K. Nguyen, Enoch A. Nagelli, Madeline Y. Ryu, Jenny Wang, R. Kenneth Sims, Kamil Woronowicz, J. Kenneth Wickiser
Published 2019-03-01

Evaluation of IAP/SMAC mimetics as latency reversal agents in primary cells and cytokine induction in in vivo models predictive of cytokine release

by B. Howell, W. Shipe, G. Adam, S. Quan, L. Li, C.N.A. Sim, R. Dunham, D. Margolis, B. Henry, D. Hazuda
Published 2019-12-01

Uniform wet-Spinning Mechanically Automated (USMA) fiber device

by Alexander N. Mitropoulos, Kylor T. Kiesewetter, Eric Horne, Jeff Butler, Joseph R. Loverde, J. Kenneth Wickiser
Published 2020-10-01

Optical Imaging Biomarkers of Drug-Induced Vascular Injury

by Shu-An Lin MS, Donna L. Suresch, Brett Connolly, Gebre Mesfin, Raymond J. Gonzalez, Manishkumar R. Patel, Diane Shevell, Timothy Johnson, Bohumil Bednar
Published 2015-01-01

Higher rectal p24 levels correlate with poor CD4 recovery in treated HIV infection

by B.J. Howell, G. Wu, S.L. Goh, P. Zuck, M. Pao, M. Deswal, R. Hoh, J.N. Martin, S.G. Deeks, M. Somsouk, D. Hazuda, P.W. Hunt
Published 2017-12-01

Pharmacological Differences between Human and Rat CGRP Receptors Are Determined by RAMP1

by S. Kane, J. Mallee, C. Salvatore, B. LeBourdelles, K. Koblan
Published 2001-01-01

fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing

by Fuqiang Zhao, Xiangjun Meng, Sherry Lu, Lynn A. Hyde, Matthew E. Kennedy, Andrea K. Houghton, Jeffrey L. Evelhoch, Catherine D.G. Hines
Published 2020-06-01

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

by Tayeba Khan, Hans Weber, Jillian DiMuzio, Andrea Matter, Belma Dogdas, Tosha Shah, Anil Thankappan, Jyoti Disa, Vasant Jadhav, Laura Lubbers, Laura Sepp-Lorenzino, Walter R Strapps, Marija Tadin-Strapps
Published 2016-01-01

Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif

by Bethany Algayer, Ann O’Brien, Aaron Momose, Dennis J. Murphy, William Procopio, David M. Tellers, Thomas J. Tucker
Published 2019-05-01

Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

by Ming-Tain Lai, Vandna Munshi, Meiqing Lu, MeiZhen Feng, Renee Hrin-Solt, Philip M. McKenna, Daria J. Hazuda, Michael D. Miller
Published 2016-09-01

Quantitative In Vivo Detection of Chlamydia muridarum Associated Inflammation in a Mouse Model Using Optical Imaging

by Manishkumar Patel, Shu-An Lin, Melissa A. Boddicker, Christopher DeMaula, Brett Connolly, Bohumil Bednar, Jon H. Heinrichs, Jeffrey G. Smith
Published 2015-01-01

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

by Ryan P. Kreiser, Aidan K. Wright, Natalie R. Block, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Benedetta Mannini, Michele Vendruscolo, Ryan Limbocker
Published 2020-11-01