Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

by Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha, Alessio Ciulli
Published 2016-11-01

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

by Stephen Patterson, Susan Wyllie, Suzanne Norval, Laste Stojanovski, Frederick RC Simeons, Jennifer L Auer, Maria Osuna-Cabello, Kevin D Read, Alan H Fairlamb
Published 2016-05-01

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

by Chiara Maniaci, Scott J. Hughes, Andrea Testa, Wenzhang Chen, Douglas J. Lamont, Sonia Rocha, Dario R. Alessi, Roberto Romeo, Alessio Ciulli
Published 2017-10-01

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

by Jessica F. Almine, Craig A. J. O’Hare, Gillian Dunphy, Ismar R. Haga, Rangeetha J. Naik, Abdelmadjid Atrih, Dympna J. Connolly, Jordan Taylor, Ian R. Kelsall, Andrew G. Bowie, Philippa M. Beard, Leonie Unterholzner
Published 2017-02-01

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

by Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner
Published 2018-02-01

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

by Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Published 2016-04-01

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

by Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, David Horn
Published 2019-07-01

Screening a protein kinase inhibitor library against Plasmodium falciparum

by Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks, Daniel James, Didier Leroy, David Waterson, Alan H. Fairlamb, Paul G. Wyatt, Ian H. Gilbert, Julie A. Frearson
Published 2017-11-01

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

by Rosalia Fernandez-Alonso, Francisco Bustos, Manon Budzyk, Pankaj Kumar, Andreas O. Helbig, Jens Hukelmann, Angus I. Lamond, Fredrik Lanner, Houjiang Zhou, Evangelia Petsalaki, Greg M. Findlay
Published 2020-03-01

A family of Type VI secretion system effector proteins that form ion-selective pores

by Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strahl, Samantha J. Pitt, Sarah J. Coulthurst
Published 2019-12-01

The multicellularity genes of dictyostelid social amoebas

by Gernot Glöckner, Hajara M. Lawal, Marius Felder, Reema Singh, Gail Singer, Cornelis J. Weijer, Pauline Schaap
Published 2016-06-01

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

by Wei-Wei Kung, Sarath Ramachandran, Nikolai Makukhin, Elvira Bruno, Alessio Ciulli
Published 2019-06-01

mRNA Cap Methylation in Pluripotency and Differentiation

by Laura Grasso, Olga Suska, Lindsay Davidson, Thomas Gonatopoulos-Pournatzis, Ritchie Williamson, Lize Wasmus, Simone Wiedlich, Mark Peggie, Marios P. Stavridis, Victoria H. Cowling
Published 2016-08-01

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

by Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts
Published 2018-12-01

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

by Kerryn Berndsen, Pawel Lis, Wondwossen M Yeshaw, Paulina S Wawro, Raja S Nirujogi, Melanie Wightman, Thomas Macartney, Mark Dorward, Axel Knebel, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi
Published 2019-10-01

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

by Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson
Published 2020-01-01

Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas

by Gillian Forbes, Zhi-hui Chen, Koryu Kin, Hajara M. Lawal, Christina Schilde, Yoko Yamada, Pauline Schaap
Published 2019-11-01

Natural variations in the biofilm-associated protein BslA from the genus Bacillus

by Ryan J. Morris, Marieke Schor, Rachel M. C. Gillespie, Ana Sofia Ferreira, Lucia Baldauf, Chris Earl, Adam Ostrowski, Laura Hobley, Keith M. Bromley, Tetyana Sukhodub, Sofia Arnaouteli, Nicola R. Stanley-Wall, Cait E. MacPhee
Published 2017-07-01

Single cell analysis of kynurenine and System L amino acid transport in T cells

by Linda V. Sinclair, Damien Neyens, George Ramsay, Peter M. Taylor, Doreen A. Cantrell
Published 2018-05-01

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

by Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond
Published 2017-09-01