LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

by Nicholas K. Vinckier, Nisha A. Patel, Ryan J. Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Hung-Ping Shih, Maike Sander
Published 2020-04-01

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast

by Robert Morey, Robert Morey, Robert Morey, Omar Farah, Omar Farah, Sampada Kallol, Sampada Kallol, Daniela F. Requena, Daniela F. Requena, Morgan Meads, Morgan Meads, Matteo Moretto-Zita, Matteo Moretto-Zita, Francesca Soncin, Francesca Soncin, Louise C. Laurent, Louise C. Laurent, Mana M. Parast, Mana M. Parast
Published 2021-09-01

Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

by Andrea S. Carlini, Roberto Gaetani, Rebecca L. Braden, Colin Luo, Karen L. Christman, Nathan C. Gianneschi
Published 2019-04-01

A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells

by Jason Ross, Julia Busch, Ellen Mintz, Damian Ng, Alexandra Stanley, David Brafman, V. Reid Sutton, Ignatia Van den Veyver, Karl Willert
Published 2014-12-01

Extracellular Matrix Hydrogel Promotes Tissue Remodeling, Arteriogenesis, and Perfusion in a Rat Hindlimb Ischemia Model

by Jessica L. Ungerleider, BS, Todd D. Johnson, PhD, Melissa J. Hernandez, BS, Dean I. Elhag, BS, Rebecca L. Braden, MS, Monika Dzieciatkowska, PhD, Kent G. Osborn, DVM, PhD, Kirk C. Hansen, PhD, Ehtisham Mahmud, MD, Karen L. Christman, PhD
Published 2016-01-01

Cardiac-Derived Extracellular Matrix Enhances Cardiogenic Properties of Human Cardiac Progenitor Cells

by Roberto Gaetani, Christopher Yin, Neha Srikumar, Rebecca Braden, Pieter A. Doevendans, Joost P. G. Sluijter, Karen L. Christman
Published 2016-09-01

Designing Acellular Injectable Biomaterial Therapeutics for Treating Myocardial Infarction and Peripheral Artery Disease

by Melissa J. Hernandez, BS, Karen L. Christman, PhD
Published 2017-04-01

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

by Irene Gallego Romero, Bryan J Pavlovic, Irene Hernando-Herraez, Xiang Zhou, Michelle C Ward, Nicholas E Banovich, Courtney L Kagan, Jonathan E Burnett, Constance H Huang, Amy Mitrano, Claudia I Chavarria, Inbar Friedrich Ben-Nun, Yingchun Li, Karen Sabatini, Trevor R Leonardo, Mana Parast, Tomas Marques-Bonet, Louise C Laurent, Jeanne F Loring, Yoav Gilad
Published 2015-06-01

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

by Ryan J Geusz, Allen Wang, Joshua Chiou, Joseph J Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P Duc Si Dong, Kyle J Gaulton, Maike Sander
Published 2021-02-01

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

by RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh, Sudarshan Anand
Published 2016-11-01

Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy

by Tiffany W Todd, Hiroshi Kokubu, Helen C Miranda, Constanza J Cortes, Albert R La Spada, Janghoo Lim
Published 2015-08-01

Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice

by Shih-Yin Tsai, Ariana A. Rodriguez, Somasish G. Dastidar, Elizabeth Del Greco, Kaili Lia Carr, Joanna M. Sitzmann, Emmeline C. Academia, Christian Michael Viray, Lizbeth Leon Martinez, Brian Stephen Kaplowitz, Travis D. Ashe, Albert R. La Spada, Brian K. Kennedy
Published 2016-08-01

Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts

by Tao Bai, Chian-Yu Peng, Ivy Aneas, Noboru Sakabe, Daniela F. Requena, Christine Billstrand, Marcelo Nobrega, Carole Ober, Mana Parast, John A. Kessler
Published 2021-10-01

Modeling preeclampsia using human induced pluripotent stem cells

by Mariko Horii, Robert Morey, Tony Bui, Ojeni Touma, Katharine K. Nelson, Hee-Young Cho, Hannah Rishik, Louise C. Laurent, Mana M. Parast
Published 2021-03-01

Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms

by Paula M. Godoy, Andrea J. Barczak, Peter DeHoff, Srimeenakshi Srinivasan, Alton Etheridge, David Galas, Saumya Das, David J. Erle, Louise C. Laurent
Published 2019-12-01

Genomic Analysis of hESC Pedigrees Identifies De Novo Mutations and Enables Determination of the Timing and Origin of Mutational Events

by Dalit Ben-Yosef, Francesca S. Boscolo, Hadar Amir, Mira Malcov, Ami Amit, Louise C. Laurent
Published 2013-09-01

Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

by Andrew P. Lieberman, Zhigang Yu, Sue Murray, Raechel Peralta, Audrey Low, Shuling Guo, Xing Xian Yu, Constanza J. Cortes, C. Frank Bennett, Brett P. Monia, Albert R. La Spada, Gene Hung
Published 2014-05-01

First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients

by Jay H. Traverse, MD, Timothy D. Henry, MD, Nabil Dib, MD, Amit N. Patel, MD, Carl Pepine, Gary L. Schaer, MD, Jessica A. DeQuach, PhD, Adam M. Kinsey, PhD, Paul Chamberlin, MD, Karen L. Christman, PhD
Published 2019-10-01

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

by Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte
Published 2016-02-01

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

by Chan-Wang Lio, Jiayuan Zhang, Edahí González-Avalos, Patrick G Hogan, Xing Chang, Anjana Rao
Published 2016-11-01