Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

by Sandra Swist, Andreas Unger, Yong Li, Anja Vöge, Marion von Frieling-Salewsky, Åsa Skärlén, Nicola Cacciani, Thomas Braun, Lars Larsson, Wolfgang A. Linke
Published 2020-09-01

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

by Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Published 2018-02-01

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

by Meike Kespohl, Niyati Vachharajani, Maik Luu, Hani Harb, Sabine Pautz, Svenja Wolff, Nina Sillner, Nina Sillner, Alesia Walker, Philippe Schmitt-Kopplin, Philippe Schmitt-Kopplin, Philippe Schmitt-Kopplin, Thomas Boettger, Harald Renz, Stefan Offermanns, Ulrich Steinhoff, Alexander Visekruna
Published 2017-08-01

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

by Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler
Published 2018-01-01

Body Temperature Measurements for Metabolic Phenotyping in Mice

by Carola W. Meyer, Youichirou Ootsuka, Andrej A. Romanovsky
Published 2017-07-01

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

by Silke Reinartz, Sonja Lieber, Jelena Pesek, Dominique T. Brandt, Alina Asafova, Florian Finkernagel, Bernard Watzer, Wolfgang Andreas Nockher, Andrea Nist, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Anne Konzer, Johannes Graumann, Robert Grosse, Thomas Worzfeld, Sabine Müller‐Brüsselbach, Rolf Müller
Published 2019-02-01

Therapeutic Targeting of Th17/Tc17 Cells Leads to Clinical Improvement of Lichen Planus

by Farzan Solimani, Robert Pollmann, Thomas Schmidt, Ansgar Schmidt, Xiang Zheng, Rajkumar Savai, Rajkumar Savai, Stefan Mühlenbein, Julia Pickert, Verena Eubel, Christian Möbs, Rüdiger Eming, Michael Hertl
Published 2019-07-01

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice

by Flávia Rezende, Franziska Moll, Maria Walter, Valeska Helfinger, Fabian Hahner, Patrick Janetzko, Christian Ringel, Andreas Weigert, Ingrid Fleming, Norbert Weissmann, Carsten Kuenne, Mario Looso, Michael A. Rieger, Peter Nawroth, Thomas Fleming, Ralf P. Brandes, Katrin Schröder
Published 2018-05-01

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro

by Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valérie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schröck, Martin Bergmann, Sabine Kliesch, Monika Kressin, Rajkumar Savai
Published 2021-07-01

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

by Milica Tosic, Anita Allen, Dominica Willmann, Christoph Lepper, Johnny Kim, Delphine Duteil, Roland Schüle
Published 2018-01-01

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

by Kathleen Hübner, Pauline Cabochette, Rodrigo Diéguez-Hurtado, Cora Wiesner, Yuki Wakayama, Kathrin S. Grassme, Marvin Hubert, Stefan Guenther, Heinz-Georg Belting, Markus Affolter, Ralf H. Adams, Benoit Vanhollebeke, Wiebke Herzog
Published 2018-11-01

Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

by Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee, Gou Young Koh
Published 2020-06-01

Post-myocardial infarction heart failure dysregulates the bone vascular niche

by Jedrzej Hoffmann, Guillermo Luxán, Wesley Tyler Abplanalp, Simone-Franziska Glaser, Tina Rasper, Ariane Fischer, Marion Muhly-Reinholz, Michael Potente, Birgit Assmus, David John, Andreas Michael Zeiher, Stefanie Dimmeler
Published 2021-06-01

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

by Volker Adams, T. Scott Bowen, Sarah Werner, Peggy Barthel, Christina Amberger, Anne Konzer, Johannes Graumann, Peter Sehr, Joe Lewis, Jan Provaznik, Vladimir Benes, Petra Büttner, Alexander Gasch, Norman Mangner, Christian C. Witt, Dittmar Labeit, Axel Linke, Siegfried Labeit
Published 2019-10-01

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes

by Maria Rödiger, Martin W. Werno, Ilka Wilhelmi, Christian Baumeier, Deike Hesse, Nina Wettschureck, Stefan Offermanns, Kyungyeun Song, Michael Krauß, Annette Schürmann
Published 2018-02-01

Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line

by Paulina Gwoździńska, Benno A. Buchbinder, Konstantin Mayer, Susanne Herold, Rory E. Morty, Rory E. Morty, Werner Seeger, Werner Seeger, István Vadász
Published 2017-05-01

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

by Jeffrey T. Kroetsch, Andrew S. Levy, Hangjun Zhang, Roozbeh Aschar-Sobbi, Darcy Lidington, Stefan Offermanns, Sergei A. Nedospasov, Peter H. Backx, Scott P. Heximer, Steffen-Sebastian Bolz
Published 2017-04-01

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

by Helge Müller-Fielitz, Marcus Stahr, Mareike Bernau, Marius Richter, Sebastian Abele, Victor Krajka, Anika Benzin, Jan Wenzel, Kathrin Kalies, Jens Mittag, Heike Heuer, Stefan Offermanns, Markus Schwaninger
Published 2017-09-01

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

by Argen Mamazhakypov, Astrid Weiß, Sven Zukunft, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Christina Vroom, Aleksandar Petrovic, Djuro Kosanovic, Norbert Weissmann, Werner Seeger, Ingrid Fleming, Marc Iglarz, Friedrich Grimminger, Hossein A. Ghofrani, Soni S. Pullamsetti, Ralph T. Schermuly
Published 2020-11-01

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells

by Lidan Zhang, Yu-taro Noguchi, Hiroyuki Nakayama, Takayuki Kaji, Kazutake Tsujikawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, Yoshiaki Okada, Takefumi Doi, Shuichi Watanabe, Thomas Braun, Yasushi Fujio, So-ichiro Fukada
Published 2019-11-01